PRKCE and GAD2

Number of citations of the paper that reports this interaction (PMID 15147202)
7

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		PRKCE	GAD2
Gene Name		protein kinase C, epsilon	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Perinuclear Region Of Cytoplasm Cell Periphery	Golgi Membrane Cytosol Plasma Membrane Cell Junction Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Signal Transducer Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity
	Biological Process	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipid Catabolic Process Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Receptor Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation	Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways		G alpha (q) signalling events Signaling by GPCR Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer Effects of PIP2 hydrolysis PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Downstream signaling of activated FGFR G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Downstream signal transduction PLC-gamma1 signalling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation	Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS		Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hemoglobin ( 19862010) Red blood cell count ( 20139978) Red blood cell traits ( 23446634 23222517)
Protein-Protein Interactions		57 interactors: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2D GRM5 HIST1H1A HK2 IKBKB ITGB1 ITGB2 KEAP1 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1	9 interactors: AGTRAP ARL6IP1 CMTM5 F10 GAD1 MAL2 PRKACA PRKCE TMEM159
Entrez ID		5581	2572
HPRD ID		01500	11817
Ensembl ID		ENSG00000171132	ENSG00000136750
Uniprot IDs		L7RTI5 Q02156	Q05329 Q5VZ30
PDB IDs		2WH0	1ES0 2OKK
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Developmental Process Anatomical Structure Development Apoptotic Process Signaling Programmed Cell Death Cell Differentiation Cell Communication Cell Death Response To Organic Substance Death Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Response To Growth Factor Response To Stimulus Positive Regulation Of Protein Phosphorylation Wound Healing Multicellular Organismal Development Cell-cell Signaling Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Cell Activation Response To Fibroblast Growth Factor Fc Receptor Signaling Pathway Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Wounding Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Synaptic Transmission Positive Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Regulation Of Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component	Positive Regulation Of Cell Migration Activation Of Phospholipase C Activity Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Positive Regulation Of Phospholipase Activity Positive Regulation Of Epithelial Cell Migration Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Regulation Of Body Fluid Levels Regulation Of Cell Migration Peptidyl-serine Phosphorylation Wound Healing Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Protein-pyridoxal-5-phosphate Linkage Histone H3-T6 Phosphorylation Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration Regulation Of Transmembrane Transporter Activity Regulation Of Cellular Component Movement Response To Wounding Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Gamma-aminobutyric Acid Biosynthetic Process Cytosolic Calcium Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Blood Coagulation, Extrinsic Pathway Regulation Of Insulin Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Glutamate Catabolic Process Peptidyl-serine Autophosphorylation
Tagcloud ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		16p11 acgh actually appreciating brwd3 cnv cnvs comorbidity debated disrupt duplication electroclinical epilepsies epileptic grin2a inheritance inherited kcnc3 microdeletions microduplications neurodevelopmental novo prrt2 re res rolandic shank1 speech tspan7	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?