LRP2BP and LRP2

Number of citations of the paper that reports this interaction (PMID 12508107)
4

Data Source:
HPRD (two hybrid, in vitro)

		LRP2BP	LRP2
Gene Name		LRP2 binding protein	low density lipoprotein receptor-related protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process		Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs			Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS			Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		7 interactors: BAI2 COPS3 LRP2 PICK1 RBM4 SNW1 TSC22D4	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		55805	4036
HPRD ID		10911	02509
Ensembl ID		ENSG00000109771	ENSG00000081479
Uniprot IDs		Q9P2M1	P98164 Q7Z5C0 Q7Z5C1
PDB IDs			2M0P
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Light Stimulus Regulation Of MRNA Splicing, Via Spliceosome Response To Radiation Regulation Of MRNA Processing Regulation Of RNA Splicing Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Stimulus Signal Transduction Developmental Process Signaling Cell Communication IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Gene Expression, Epigenetic Regulation Of Vitamin D Receptor Signaling Pathway Circadian Regulation Of Translation DNA Methylation Involved In Embryo Development Nervous System Development Negative Regulation Of Translation In Response To Stress Cullin Deneddylation Cellular Response To Stimulus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Dendritic Spine Maintenance Cytoplasmic Translational Initiation Positive Regulation By Host Of Viral Transcription Protein Deneddylation Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Vitamin D Metabolic Process Negative Regulation Of Actin Nucleation RNA Splicing Multicellular Organismal Development Cytoplasmic Translation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Translation In Response To Stress Negative Regulation Of Gene Expression Long Term Synaptic Depression Negative Regulation Of Biosynthetic Process Anatomical Structure Development Positive Regulation Of Receptor Internalization Negative Regulation Of Translational Initiation Regulation Of Arp2/3 Complex-mediated Actin Nucleation MRNA Processing Dendritic Spine Organization Entrainment Of Circadian Clock By Photoperiod DNA Methylation Involved In Gamete Generation Regulation Of Histone H3-K4 Methylation Regulation Of Actin Nucleation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?			adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?			adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?