CDK5RAP2 and FBXO25

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK5RAP2	FBXO25
Gene Name		CDK5 regulatory subunit associated protein 2	F-box protein 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cell Junction Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Chromosome Segregation Brain Development Neurogenesis Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Centrosome Organization Regulation Of Spindle Checkpoint	Protein Ubiquitination
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-Protein Interactions		24 interactors: ABCA2 C14orf1 CDK5 CDK5R1 CRMP1 EEF1G FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		55755	26260
HPRD ID		09740	16439
Ensembl ID		ENSG00000136861	ENSG00000147364
Uniprot IDs		B3KVI2 B9EG74 Q7Z3M0 Q96SN8	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Serine Phosphorylation Of STAT3 Protein Regulation Of Protein Binding Serine Phosphorylation Of STAT Protein Regulation Of Microtubule-based Process Retrograde Axon Cargo Transport Regulation Of Intracellular Transport Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Process Regulation Of Binding Limbic System Development Regulation Of Neuron Death Regulation Of Organelle Organization Axon Development Cerebellum Development Microtubule-based Movement Cellular Component Assembly Metencephalon Development Negative Regulation Of Axon Extension Movement Of Cell Or Subcellular Component Anterograde Axon Cargo Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Hindbrain Development Microtubule-based Process Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Nervous System Development Neuron Projection Development Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Morphogenesis Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Death Cell Projection Morphogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Pre-mRNA Catabolic Process DNA Endoreduplication Regulation Of Cell Projection Organization Cell Part Morphogenesis Axon Cargo Transport Regulation Of Cytoskeleton Organization Response To Organic Cyclic Compound Positive Regulation Of Intracellular Transport Regulation Of Cell Cycle Organelle Organization	Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process
Tagcloud ?		acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?		acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?