PRKAR1A and C2orf88

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRKAR1A	C2orf88
Gene Name		protein kinase, cAMP-dependent, regulatory, type I, alpha	chromosome 2 open reading frame 88
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Neuromuscular Junction Protein Complex Ciliary Base	Plasma Membrane
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Kinase A Regulatory Subunit Binding
	Biological Process	Mesoderm Formation Renal Water Homeostasis Energy Reserve Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Water Transport Female Meiotic Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf44 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MAPT MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WNK1 ZBED1	8 interactors: ARMC7 BATF2 MYOD1 NFKBIL1 PRKAR1A RALGPS1 TDP2 ZMIZ2
Entrez ID		5573	84281
HPRD ID		01786	14436
Ensembl ID		ENSG00000108946	ENSG00000187699
Uniprot IDs		B2R5T5 K7ER48 P10644 Q68DQ4	Q9BSF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Protein Kinase A Signaling Regulation Of Body Fluid Levels Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Regulation Of Protein Phosphorylation Response To Stress Response To Growth Factor Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase Activity Activation Of Phospholipase C Activity Cell Motility Regulation Of Phosphorus Metabolic Process Cell Activation Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Signaling Locomotion Cellular Response To Peptide Hormone Stimulus Mitotic Cell Cycle Cell Communication Cellular Response To Peptide Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Phospholipase Activity Heterochromatin Organization	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Myoblast Fate Determination Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Fiber Adaptation Striated Muscle Cell Development Muscle Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Skeletal Muscle Tissue Regeneration Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of CAMP-dependent Protein Kinase Activity Myoblast Fate Commitment Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Skeletal Muscle Adaptation Regulation Of Transcription, DNA-templated Striated Muscle Tissue Development Muscle Cell Differentiation Regulation Of CAMP-dependent Protein Kinase Activity Muscle Tissue Development Activation Of Protein Kinase A Activity Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Muscle Cell Fate Commitment Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Cellular Response To Estradiol Stimulus Regulation Of Skeletal Muscle Fiber Development Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Meiotic Cell Cycle Regulation Of Myoblast Fusion Defense Response To Protozoan Skeletal Muscle Fiber Development Cytoplasmic Sequestering Of Protein Myeloid Dendritic Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Response To Protozoan Myeloid Dendritic Cell Activation Regulation Of Cellular Process Growth
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?