PACS1 and VAMP4

Number of citations of the paper that reports this interaction (PMID 14608369)
20

Data Source:
HPRD (in vivo, in vitro)

		PACS1	VAMP4
Gene Name		phosphofurin acidic cluster sorting protein 1	vesicle-associated membrane protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol COPI-coated Vesicle	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Cell Surface Integral Component Of Membrane SNARE Complex
	Molecular Function	Protein Binding Ion Channel Binding	SNARE Binding SNAP Receptor Activity
	Biological Process	Protein Targeting To Golgi Viral Process Regulation Of Defense Response To Virus By Virus Protein Targeting To Plasma Membrane	Microtubule Cytoskeleton Organization Exocytosis ER To Golgi Vesicle-mediated Transport SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Golgi Ribbon Formation
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		10 interactors: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4	9 interactors: AP1M1 BCL2L13 CCDC155 CSNK2A1 PACS1 SNAP29 STX16 STX4 STX6
Entrez ID		55690	8674
HPRD ID		06320	06070
Ensembl ID		ENSG00000175115	ENSG00000117533
Uniprot IDs		Q6VY07	O75379 Q6IAZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Catabolic Process Liver Development Cell Death Death Cell Surface Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Phosphate-containing Compound Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Cellular Response To Potassium Ion Starvation Negative Regulation Of Cellular Protein Catabolic Process Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Regulation Of Endothelial Cell Proliferation Response To Oxidative Stress Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Cellular Protein Modification Process Response To Inorganic Substance Protein Kinase D Signaling Leading Edge Cell Differentiation Nerve Growth Factor Production Metanephric Smooth Muscle Tissue Development Detection Of Nodal Flow Renal Artery Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Gland Development Regulation Of Receptor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Protein Catabolic Process Transport Response To Hydrogen Peroxide Negative Regulation Of Transforming Growth Factor Beta1 Production	Vesicle Fusion Vesicle Organization Organelle Fusion Golgi Vesicle Transport Membrane Fusion Membrane Organization Establishment Of Localization In Cell Golgi Ribbon Formation Protein Transport Cellular Localization Vesicle-mediated Transport Establishment Of Protein Localization Synaptic Vesicle Fusion To Presynaptic Membrane Intracellular Protein Transport Protein Localization Regulation Of Defense Response To Virus By Virus Endosomal Transport Cellular Protein Localization Intracellular Transport Intra-Golgi Vesicle-mediated Transport Synaptic Vesicle Exocytosis Establishment Of Organelle Localization Retrograde Transport, Endosome To Golgi Organelle Organization Golgi Organization Chromosome Localization To Nuclear Envelope Involved In Synapsis Organelle Localization Vesicle Docking Regulation Of Defense Response To Virus Endomembrane System Organization Post-Golgi Vesicle-mediated Transport Membrane Docking Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Eosinophil Degranulation Regulation Of Neurotransmitter Levels Neurotransmitter Transport Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Establishment Of Vesicle Localization Regulation Of Cysteine-type Endopeptidase Activity Vesicle Localization Positive Regulation Of Protein Localization To Cell Surface Autophagic Vacuole Fusion Pigment Granule Maturation Endosome To Melanosome Transport Positive Regulation Of Immunoglobulin Secretion Synaptic Vesicle Priming Transport Cellular Pigment Accumulation SNARE Complex Assembly
Tagcloud ?		acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored	adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 verify vps4b wizened
Tagcloud (Difference) ?		acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored	adm adriamycin arrb2 bigger cblb chip cryopreservation doubling effectors endoperoxide exocytosis exudation gliomas impulse ingestion mdr medip ontology pard6b pgp pkcalpha rh123 sgh snap47 tgfb1 vamp3 verify vps4b wizened
Tagcloud (Intersection) ?