PRKACG and CDK17

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRKACG	CDK17
Gene Name		protein kinase, cAMP-dependent, catalytic, gamma	cyclin-dependent kinase 17
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Ciliary Base
	Molecular Function	CAMP-dependent Protein Kinase Activity ATP Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Spermatogenesis Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus	Protein Phosphorylation Regulation Of Cell Cycle
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS			Phospholipid levels (plasma) ( 22359512)
Protein-Protein Interactions		5 interactors: CDK17 CETP HMGN1 TNP1 TNP2	8 interactors: APP EPHA2 PRKACG TDRD7 TGFBR1 YWHAG YWHAQ YWHAZ
Entrez ID		5568	5128
HPRD ID		01483	09141
Ensembl ID		ENSG00000165059	ENSG00000059758
Uniprot IDs		P22612	Q00537
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Single Fertilization Male Pronucleus Assembly Fertilization Triglyceride Transport Post-embryonic Camera-type Eye Morphogenesis Pyrimidine Dimer Repair By Nucleotide-excision Repair Penetration Of Zona Pellucida Post-embryonic Organ Morphogenesis Very-low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Post-embryonic Camera-type Eye Development Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Elongation Low-density Lipoprotein Particle Remodeling Response To UV-C Pyrimidine Dimer Repair Nucleosome Disassembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation High-density Lipoprotein Particle Remodeling Response To UV-B Reverse Cholesterol Transport Spermatogenesis Regulation Of Development, Heterochronic Male Gamete Generation Single Strand Break Repair Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Acrosome Reaction DNA Repair Positive Regulation Of DNA-templated Transcription, Elongation Spermatid Nucleus Differentiation Gamete Generation Histone Exchange Chromatin Silencing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Chromatin Organization Transcription-coupled Nucleotide-excision Repair Binding Of Sperm To Zona Pellucida Regulation Of Macrophage Derived Foam Cell Differentiation Calcium Ion-dependent Exocytosis Anion Homeostasis Sexual Reproduction Multicellular Organismal Reproductive Process Sperm-egg Recognition Regulation Of DNA-templated Transcription, Elongation Phosphatidylcholine Metabolic Process	Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Lens Development In Camera-type Eye Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Transport Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death System Development Lens Morphogenesis In Camera-type Eye Regulation Of Phosphorus Metabolic Process Response To Wounding Lens Fiber Cell Differentiation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Sexual Reproduction Multicellular Organismal Development Organ Development Anatomical Structure Development Phosphorylation Regulation Of Cellular Component Organization Signal Transduction Camera-type Eye Development Reproduction Developmental Process Regulation Of Protein Phosphorylation Eye Development Positive Regulation Of Organelle Organization Signaling Immune System Process Protein Targeting
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?