WDR33 and WWOX

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down, affinity chromatography technology)

		WDR33	WWOX
Gene Name		WD repeat domain 33	WW domain containing oxidoreductase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Collagen Trimer Nucleus Nucleoplasm Nucleolus MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex
	Molecular Function	Poly(A) RNA Binding	RNA Polymerase II Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Protein Dimerization Activity Cofactor Binding Coenzyme Binding
	Biological Process	Postreplication Repair MRNA Polyadenylation MRNA Cleavage Spermatogenesis	Osteoblast Differentiation Steroid Metabolic Process Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs
Diseases
GWAS			Anorexia nervosa ( 23568457) Cardiac structure and function ( 19584346) Metabolite levels (5-HIAA) ( 23319000) Obesity ( 21552555) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Radiation response ( 20923822) Reasoning ( 21107309) Response to amphetamines ( 22952603) Type 2 diabetes ( 22158537)
Protein-Protein Interactions		14 interactors: CDK4 EEF1G GIT1 KAT7 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UTP14A WWOX ZBTB16 ZHX1	17 interactors: CPSF2 CPSF7 EZR FIP1L1 HNRNPK LATS1 MAPK8 NUDT21 SF3B3 SRC TCERG1 TNK2 TP53 TP73 UBB WDR33 WIPF2
Entrez ID		55339	51741
HPRD ID		11680	05501
Ensembl ID		ENSG00000136709	ENSG00000186153
Uniprot IDs		Q9C0J8	Q9NZC7
PDB IDs			1WMV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Anterior/posterior Pattern Specification Chromatin Organization System Development Negative Regulation Of Cell Differentiation Developmental Process Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chondrocyte Differentiation Regulation Of Apoptotic Process Nervous System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cartilage Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Lens Development In Camera-type Eye Multicellular Organismal Development Regulation Of Cell Cycle Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Apoptotic Process Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Programmed Cell Death Negative Regulation Of Cell Cycle Negative Regulation Of Helicase Activity Signal Transduction By P53 Class Mediator Chromosome Organization Regulation Of Cell Projection Assembly Cell Death Death Pattern Specification Process	MRNA Processing MRNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Processing MRNA 3'-end Processing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Polyadenylation Protein Tetramerization RNA Metabolic Process RNA Polyadenylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Termination Of RNA Polymerase II Transcription Gene Expression RNA Splicing Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Phosphorylation DNA-templated Transcription, Termination DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Gene Expression Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process MRNA Cleavage Regulation Of Protein Phosphorylation
Tagcloud ?			breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Difference) ?			breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Intersection) ?