PPP3CC and SDC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PPP3CC	SDC2
Gene Name		protein phosphatase 3, catalytic subunit, gamma isozyme	syndecan 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Golgi Lumen Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Lysosomal Lumen Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Calmodulin Binding Metal Ion Binding	Protein Binding PDZ Domain Binding
	Biological Process	Apoptotic Process Dephosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Retinoid Metabolic Process Response To Hypoxia Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Response To Caffeine Wound Healing Small Molecule Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		Activation of BAD and translocation to mitochondria Signaling by GPCR Opioid Signalling Programmed Cell Death DARPP-32 events Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism EPHB-mediated forward signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D EPH-Ephrin signaling A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		11 interactors: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC SDC2 TGFBR1 THAP7	26 interactors: BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF KAL1 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		5533	6383
HPRD ID		00236	00803
Ensembl ID		ENSG00000120910	ENSG00000169439
Uniprot IDs		P48454	E9PBI9 P34741
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Axonogenesis Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Regulation Of Binding Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Axon Guidance Cell Part Morphogenesis Generation Of Neurons Regulation Of Cell Differentiation Regulation Of Protein Binding Neurogenesis Neuron Development Cell Development Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Projection Organization Chemotaxis Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Gonad Development Locomotion Positive Regulation Of Signal Transduction Development Of Primary Sexual Characteristics Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Cell Proliferation Protein Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Wounding Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Phosphorylation Nervous System Development Developmental Growth Sex Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Thymus Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Sexual Reproduction	Regulation Of Body Fluid Levels Platelet Activation Wound Healing Response To Wounding Blood Coagulation Hemostasis Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Epithelial Cell Proliferation Cell Activation Regulation Of Angiogenesis Regulation Of Cell Migration Multicellular Organismal Development Regulation Of Epithelial Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Cell Proliferation Response To Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Locomotion Positive Regulation Of Signal Transduction System Development Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Migration Anatomical Structure Development Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stress Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Cell Development Histone H3-T6 Phosphorylation
Tagcloud ?		ankk1 ankyrin catechol comt contradicting disabilities drd2 economical google htt industrialized isozyme keywords kibra lifelong nefh neurofilament neurotrophic nos3 penetrating repercussions researches return roughly scholar slc6a4 solute tbi traumatic	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Difference) ?		ankk1 ankyrin catechol comt contradicting disabilities drd2 economical google htt industrialized isozyme keywords kibra lifelong nefh neurofilament neurotrophic nos3 penetrating repercussions researches return roughly scholar slc6a4 solute tbi traumatic	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Intersection) ?