PIWIL2 and DDX4

Number of citations of the paper that reports this interaction (PMID 14736746)
153

Data Source:
HPRD (in vivo, in vitro)

		PIWIL2	DDX4
Gene Name		piwi-like RNA-mediated gene silencing 2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Polysome Chromatoid Body P Granule Pi-body	Nucleus Cytoplasm Chromatoid Body Perinuclear Region Of Cytoplasm Pi-body PiP-body
	Molecular Function	MRNA Binding PiRNA Binding	Nucleic Acid Binding Helicase Activity ATP Binding
	Biological Process	RNA 5'-end Processing Multicellular Organismal Development Spermatogenesis Gene Expression Germ-line Stem Cell Maintenance Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Positive Regulation Of Translation Oogenesis Meiotic Cell Cycle Positive Regulation Of Meiosis I	Male Meiosis I Multicellular Organismal Development Spermatogenesis Gene Expression Sperm Motility Regulation Of Protein Localization PiRNA Metabolic Process
Pathways		PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways	PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		2 interactors: DDX4 DICER1	5 interactors: PIWIL2 RANBP9 SPSB1 SPSB2 SPSB4
Entrez ID		55124	54514
HPRD ID		11434	05593
Ensembl ID		ENSG00000197181	ENSG00000152670
Uniprot IDs		Q8TC59	Q9NQI0
PDB IDs		3O7X 3QIR
Enriched GO Terms of Interacting Partners?		Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Zygote Asymmetric Cell Division Targeting Of MRNA For Destruction Involved In RNA Interference Myoblast Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation NcRNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Positive Regulation Of Schwann Cell Differentiation Asymmetric Cell Division Regulation Of Schwann Cell Differentiation Positive Regulation Of Myelination Regulation Of MiRNA Metabolic Process Production Of SiRNA Involved In RNA Interference Negative Regulation Of Glial Cell Proliferation Olfactory Bulb Interneuron Differentiation RNA Interference Pre-miRNA Processing Ganglion Development Regulation Of Odontogenesis Of Dentin-containing Tooth Intestinal Epithelial Cell Development Apoptotic DNA Fragmentation Intestinal Epithelial Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Cell Cycle Process Skeletal Muscle Tissue Regeneration MRNA Stabilization Male Meiosis I Regulation Of Odontogenesis Apoptotic Nuclear Changes Myelin Assembly PiRNA Metabolic Process Hair Follicle Morphogenesis Gene Silencing By MiRNA Cellular Response To DsRNA Reproductive Process Positive Regulation Of Glial Cell Differentiation Posttranscriptional Gene Silencing Cell Cycle Inner Ear Receptor Cell Development Epidermis Morphogenesis Olfactory Bulb Development Spleen Development Olfactory Lobe Development Regulation Of Oligodendrocyte Differentiation Spinal Cord Motor Neuron Differentiation	Protein Ubiquitination Protein Modification By Small Protein Conjugation RNA 5'-end Processing Positive Regulation Of Meiosis I Germ-line Stem Cell Maintenance Regulation Of Meiosis I
Tagcloud ?		apoptosis binds fas filament finding hybrid increases indicates inhibits interacting intermediate k8 keratin p38 partner plays protecting protects represses revealing ser src stimuli supports triple tumorigenesis ubiquitin widely	122c 2012cb944901 9qh azoospermia blimp1 dazl declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Difference) ?		apoptosis binds fas filament finding hybrid increases indicates inhibits interacting intermediate k8 keratin p38 partner plays protecting protects represses revealing ser src stimuli supports triple tumorigenesis ubiquitin widely	122c 2012cb944901 9qh azoospermia blimp1 dazl declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Intersection) ?