USP47 and MED29

Number of citations of the paper that reports this interaction (PMID 14576168)
11

Data Source:
HPRD (in vitro)

		USP47	MED29
Gene Name		ubiquitin specific peptidase 47	mediator complex subunit 29
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleoplasm Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding WD40-repeat Domain Binding	Protein Binding
	Biological Process	Base-excision Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Cellular Response To UV Monoubiquitinated Protein Deubiquitination Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AP4M1 MED29 MED9 PLA2G2A SNCA	9 interactors: MED1 MED12 MED13 MED14 MED17 MED20 MED21 MED9 USP47
Entrez ID		55031	55588
HPRD ID		11668	13748
Ensembl ID		ENSG00000170242	ENSG00000063322
Uniprot IDs		Q96K76	B4DUA7 Q9NX70
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Synaptic Vesicle Recycling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Phosphatidylinositol Acyl-chain Remodeling Regulation Of Neurotransmitter Uptake Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Negative Regulation Of Microtubule Polymerization Positive Regulation Of Neurotransmitter Secretion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Acyl-CoA Biosynthetic Process Cellular Response To Epinephrine Stimulus Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Catecholamine Biosynthetic Process Regulation Of Synaptic Transmission, Dopaminergic Response To Epinephrine Regulation Of Dopamine Metabolic Process Response To Bacterium Response To Magnesium Ion Phosphatidylethanolamine Acyl-chain Remodeling	Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Maintenance Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Stem Cell Development Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation Stem Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Axis Elongation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cell Development Base-excision Repair Thyroid Hormone Mediated Signaling Pathway Positive Regulation Of Metabolic Process Cellular Metabolic Process Developmental Growth Involved In Morphogenesis Enucleate Erythrocyte Development Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of G0 To G1 Transition Axis Elongation Involved In Somitogenesis Depyrimidination Regulation Of Organ Morphogenesis
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