PPP1CB and PPP1R12B

Number of citations of the paper that reports this interaction (PMID 9570949)
7

Data Source:
HPRD (in vitro)

		PPP1CB	PPP1R12B
Gene Name		protein phosphatase 1, catalytic subunit, beta isozyme	protein phosphatase 1, regulatory subunit 12B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Focal Adhesion Glycogen Granule Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity	Enzyme Activator Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Regulation Of Cell Adhesion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Cell Division	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Muscle Contraction Signal Transduction Positive Regulation Of Catalytic Activity
Pathways		Loss of Function of TGFBR2 in Cancer Metabolism of lipids and lipoproteins Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer G2/M Transition TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Regulation of PLK1 Activity at G2/M Transition Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Mitotic G2-G2/M phases SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: AURKA BRCA1 CSRNP2 NONO PPP1R12B PPP1R12C PPP1R16A PPP1R2P3 PPP1R3C PPP1R9B PRKAR2A PTK2 RB1 SH2D4A TLX1 TP53BP2 WBP11 ZFYVE9	3 interactors: IL16 PPP1CB PRKG1
Entrez ID		5500	4660
HPRD ID		11792	04794
Ensembl ID		ENSG00000213639	ENSG00000077157
Uniprot IDs		P62140	E1CKY7 O60237
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Dephosphorylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Protein Catabolic Process Apoptotic Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Programmed Cell Death Positive Regulation Of Cell Cycle Process Cell Cycle Process Cell Death Death Regulation Of Centrosome Cycle Centrosome Cycle Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cell Division Neuron Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Spindle Checkpoint Regulation Of Lipid Kinase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Glycogen Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Glycogen Catabolic Process Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Smooth Muscle Contraction Regulation Of Cell Adhesion Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Negative Regulation Of Platelet Activation Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Negative Regulation Of Muscle Contraction Relaxation Of Muscle Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cell Migration Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Positive Chemotaxis Cyclic-nucleotide-mediated Signaling Regulation Of Platelet Activation Vasodilation Cell Motility Regulation Of Glycogen Metabolic Process Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Glycogen Metabolic Process Locomotion Negative Regulation Of Wound Healing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Blood Vessel Size Regulation Of Tube Size Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Blood Coagulation Regulation Of Glucose Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Leukocyte Chemotaxis Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Chemotaxis G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		3xflag atp5c1 compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?