RNF111 and CTBP1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		RNF111	CTBP1
Gene Name		ring finger protein 111	C-terminal binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Transcriptional Repressor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity SUMO Polymer Binding SMAD Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Protein Homodimerization Activity NAD Binding Repressing Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Gene Expression Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Phosphorylation Golgi Organization Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Asperger disorder ( 21182207) Metabolite levels ( 22916037)
Protein-Protein Interactions		39 interactors: ACTN3 ANAPC11 AXIN1 CREB1 CSNK2A1 CTBP1 DTX3L EDARADD KRTAP5-9 LCE4A LRSAM1 MARCH7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO2 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2Q2 UBE2V1 UBE2W	83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FOXP1 FOXP2 FUNDC1 GTF2B HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HIST3H3 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCOR LCORL LNX1 MAPK9 MARCH10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 ORC4 PIAS2 PLCB1 PNN PRKAA1 RAI2 RB1 RBBP5 RBBP8 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TCF7L2 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		54778	1487
HPRD ID		09318	04015
Ensembl ID		ENSG00000157450	ENSG00000159692
Uniprot IDs		Q6ZNA4	Q13363
PDB IDs		2KIZ	1MX3
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Protein Monoubiquitination Negative Regulation Of Biosynthetic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Metabolic Process Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition TRIF-dependent Toll-like Receptor Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Chromosome Organization Positive Regulation Of Metabolic Process Developmental Process Chromatin Modification Embryo Development Transcription From RNA Polymerase II Promoter Anatomical Structure Development Chromatin Organization Histone H4 Deacetylation Regulation Of Cell Differentiation Organelle Organization Organ Development Metabolic Process Regulation Of Cellular Process System Development
Tagcloud ?			adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Difference) ?			adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Intersection) ?