LZTFL1 and FZD5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LZTFL1	FZD5
Gene Name		leucine zipper transcription factor-like 1	frizzled class receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol BBSome	Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Complex Binding Identical Protein Binding	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Organelle Organization Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane	Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FZD5 SDCBP WDYHV1	11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		54585	7855
HPRD ID		07586	03427
Ensembl ID		ENSG00000163818	ENSG00000163251
Uniprot IDs		Q9NQ48	Q13467
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Chorionic Trophoblast Cell Proliferation Spemann Organizer Formation Positive Regulation Of Extracellular Vesicular Exosome Assembly Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Extracellular Vesicular Exosome Assembly Chorionic Trophoblast Cell Differentiation Chorion Development Positive Regulation Of MAPK Cascade Regulation Of Tight Junction Assembly Post-embryonic Camera-type Eye Development Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Branching Involved In Labyrinthine Layer Morphogenesis Substrate-dependent Cell Migration, Cell Extension Regulation Of MAPK Cascade Anterior/posterior Axis Specification, Embryo Labyrinthine Layer Morphogenesis Apoptotic Process Involved In Morphogenesis Dorsal/ventral Axis Specification Positive Regulation Of Organelle Assembly Labyrinthine Layer Blood Vessel Development Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Involved In Development Embryonic Placenta Morphogenesis Positive Regulation Of Phosphorylation Non-canonical Wnt Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell-cell Signaling Substrate-dependent Cell Migration Placenta Blood Vessel Development Developmental Programmed Cell Death Developmental Induction Positive Regulation Of Interferon-gamma Production Neuron Differentiation Embryonic Axis Specification Labyrinthine Layer Development Embryonic Camera-type Eye Development Regulation Of Cell Junction Assembly Positive Regulation Of Exocytosis Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Anterior/posterior Axis Specification Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity	Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development
Tagcloud ?			aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?			aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?