POLR2B and SUB1

Number of citations of the paper that reports this interaction (PMID 10024883)
76

Data Source:
BioGRID (pull down)

		POLR2B	SUB1
Gene Name		polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	SUB1 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Membrane	Nucleus Transcription Factor Complex Nucleolus Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Activity DNA Binding Chromatin Binding Protein Binding Ribonucleoside Binding Poly(A) RNA Binding Metal Ion Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Signal Transduction
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Height ( 20881960)
Protein-Protein Interactions		18 interactors: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 NEDD4 POLR2A POLR2C POLR2D POLR2H POLR2K POLR2L SUB1 ZSCAN1	19 interactors: ADAP1 APP CBX5 CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST SP1 TAF1 TBP
Entrez ID		5431	10923
HPRD ID		15943	02737
Ensembl ID		ENSG00000047315	ENSG00000113387
Uniprot IDs		C9J2Y9 C9J4M6 P30876	P53999 Q6IBA2
PDB IDs			1PCF 2C62 2PHE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Regulation Of Viral Transcription Positive Regulation Of Viral Process Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation Viral Process Regulation Of Viral Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Nucleotide-excision Repair DNA-templated Transcription, Initiation PiRNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Termination Of RNA Polymerase I Transcription Somatic Stem Cell Maintenance Transcription Elongation From RNA Polymerase I Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase I Promoter RNA Biosynthetic Process Transcription From RNA Polymerase I Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Positive Regulation Of Metabolic Process DNA Repair MRNA Processing Stem Cell Maintenance Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic MRNA Metabolic Process Gene Expression RNA Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome Regulation Of Type I Interferon Production RNA Splicing, Via Transesterification Reactions Stem Cell Development DNA Metabolic Process	Transcription From RNA Polymerase II Promoter RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of Viral Process Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Interaction With Symbiont Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Stress MRNA Processing Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Cellular Process MRNA Metabolic Process Nucleotide-excision Repair
Tagcloud ?			biosynthetic choline coactivators demethylation dot1 ecm5 gcn5 gis1 icre ino2 ino4 inositol jhd1 jhd2 lys36 med15 med18 med19 med2 med3 mediator methyltransferase modify phospholipid recruit rph1 set1 set2 snf1
Tagcloud (Difference) ?			biosynthetic choline coactivators demethylation dot1 ecm5 gcn5 gis1 icre ino2 ino4 inositol jhd1 jhd2 lys36 med15 med18 med19 med2 med3 mediator methyltransferase modify phospholipid recruit rph1 set1 set2 snf1
Tagcloud (Intersection) ?