PLXNA1 and RND1

Number of citations of the paper that reports this interaction (PMID 11108845)
35

Data Source:
HPRD (in vitro)

		PLXNA1	RND1
Gene Name		plexin A1	Rho family GTPase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Cytosol Cytoskeleton Plasma Membrane Adherens Junction
	Molecular Function	Receptor Activity Semaphorin Receptor Activity	GTPase Activity Receptor Binding Protein Binding GTP Binding
	Biological Process	Multicellular Organismal Development Axon Guidance Regulation Of Smooth Muscle Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway	Actin Filament Organization Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Axon Guidance Metabolic Process Neuron Remodeling
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		MRI atrophy measures ( 21116278)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		7 interactors: AKT1 FES NRP1 PLXNB1 RHOD RND1 SEMA6D	12 interactors: ARHGAP5 CREB3L2 FRS2 FRS3 GRB7 ID3 PDE6D PLXNA1 PLXNB1 PLXNB2 UBXN11 ZNF212
Entrez ID		5361	27289
HPRD ID		11868	12357
Ensembl ID		ENSG00000114554	ENSG00000172602
Uniprot IDs		Q9UIW2	Q92730
PDB IDs			2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?		Cell Projection Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Neuron Projection Morphogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Negative Regulation Of Osteoblast Proliferation Neuron Differentiation Nervous System Development Regulation Of Cell Projection Organization Locomotion Regulation Of Neuron Differentiation Regulation Of Cell Migration Movement Of Cell Or Subcellular Component Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Osteoblast Proliferation Regulation Of Neurogenesis Positive Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Projection Organization Cell Differentiation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Smooth Muscle Cell Migration Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation	Semaphorin-plexin Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Organ Development Regulation Of Locomotion Neuroblast Proliferation Regulation Of Cellular Component Movement Regulation Of Rho GTPase Activity Regulation Of Rho Protein Signal Transduction Generation Of Neurons Positive Regulation Of Axonogenesis Response To Stimulus Stem Cell Proliferation Neurogenesis Tissue Development Signal Transduction Neural Precursor Cell Proliferation Epithelium Development Gland Development System Development Morphogenesis Of An Epithelium Signaling Optic Placode Formation Involved In Camera-type Eye Formation Cell Communication Regulation Of Ras GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Optic Placode Formation Gland Morphogenesis Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Cell Differentiation Nervous System Development Tissue Morphogenesis Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Catalytic Activity Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis
Tagcloud ?			bioinformatics colonization conversely conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated
Tagcloud (Difference) ?			bioinformatics colonization conversely conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated
Tagcloud (Intersection) ?