PLP2 and IKBKAP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLP2	IKBKAP
Gene Name		proteolipid protein 2 (colonic epithelium-enriched)	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	Protein Binding Ion Transmembrane Transporter Activity Chemokine Binding	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Ion Transmembrane Transport	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BCAP31 CCDC155 CCR1 CLN8 DLGAP4 IKBKAP SHBG TMEM79 VKORC1	26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		5355	8518
HPRD ID		02121	04763
Ensembl ID		ENSG00000102007	ENSG00000070061
Uniprot IDs		Q04941	O95163 Q8N516
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Localization To Nuclear Envelope Involved In Synapsis Primary Spermatocyte Growth Spermatogenesis Male Gamete Generation L-glutamate Uptake Involved In Synaptic Transmission Homeostatic Process Cuticle Development Gamete Generation Cornification Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Age-dependent Response To Oxidative Stress Protein Localization To Endoplasmic Reticulum Exit Site Vitamin K Metabolic Process Sexual Reproduction Multicellular Organismal Reproductive Process Somatic Motor Neuron Differentiation Multicellular Organism Reproduction L-glutamate Import Chemical Homeostasis Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Monocyte Chemotaxis Establishment Of Localization In Cell Neurotransmitter Uptake Calcium-mediated Signaling Using Intracellular Calcium Source Peptidyl-glutamic Acid Carboxylation Cellular Calcium Ion Homeostasis Regulation Of Monocyte Chemotaxis Dendritic Cell Chemotaxis Neurofilament Cytoskeleton Organization Reproduction Calcium Ion Homeostasis Neuromuscular Process Controlling Posture Amino Acid Import Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Mitochondrial Calcium Ion Homeostasis Establishment Of Skin Barrier Exocytosis Positive Regulation Of Cellular Component Movement	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production
Tagcloud ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Difference) ?		antiviral bona coronavirus coronaviruses deubiquitinates engages ensure escape fide hcov ifnbeta immunopathology innate interferon irf7 mdm2 meanwhile nl63 nonstructural oncoprotein papain plps proteases proteasomal rampant reveals stabilizes suppressors usually	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Intersection) ?