ATP6V0B and IRAK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATP6V0B	IRAK3
Gene Name		ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	interleukin-1 receptor-associated kinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Nucleus Cytoplasm Interleukin-1 Receptor Complex
	Molecular Function	Transporter Activity Hydrogen Ion Transmembrane Transporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Interaction With Host Transmembrane Transport Phagosome Maturation	Negative Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Cytokine Signaling in Immune system Interleukin-1 signaling Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: FAS IRAK3 SNTA1 YWHAG	17 interactors: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		533	11213
HPRD ID		04759	05123
Ensembl ID		ENSG00000117410	ENSG00000090376
Uniprot IDs		E9PNL3 Q99437	Q9Y616
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Tolerance Induction Regulation Of Vasoconstriction By Circulating Norepinephrine Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Motor Neuron Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Peptidyl-cysteine S-nitrosylation Necroptotic Signaling Pathway Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Apoptotic Signaling Pathway Inflammatory Cell Apoptotic Process Negative Regulation Of Immune System Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Negative Regulation Of Phosphorylation Cellular Response To Organic Substance Pantothenate Metabolic Process Regulation Of Cellular Component Organization Response To Peptidoglycan Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Lithium Ion T Cell Apoptotic Process Interleukin-1-mediated Signaling Pathway Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Ventricular Cardiac Muscle Cell Action Potential Cellular Response To Cytokine Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Interleukin-12 Production Positive Regulation Of Programmed Cell Death Regulation Of Membrane Repolarization Thymic T Cell Selection Acetyl-CoA Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Long-chain Fatty-acyl-CoA Metabolic Process Regulation Of Catalytic Activity	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Cellular Response To Lipid Regulation Of Innate Immune Response Response To Lipopolysaccharide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Molecule Of Bacterial Origin Toll-like Receptor 9 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 JNK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Bacterium Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Lipid Regulation Of Immune Response Regulation Of Immune System Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Immune Response Response To Cytokine Response To Other Organism Response To Biotic Stimulus Cellular Response To Interleukin-1 Inflammatory Response Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction
Tagcloud ?			a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Difference) ?			a20 acutely antiphospholipid anx2 aps attenuate chronically explored finger firstly glycoprotein gpi irak1 irak4 iraks lentiviruses leukaemia lv md monocytic paclitaxel rnai tf thp tlr4 toll traf4 traf6 trafs
Tagcloud (Intersection) ?