PKP2 and POLR3A

Number of citations of the paper that reports this interaction (PMID 11416169)
26

Data Source:
HPRD (in vitro)

		PKP2	POLR3A
Gene Name		plakophilin 2	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome	Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol Membrane
	Molecular Function	Molecular_function Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Protein Complex Scaffold Ion Channel Binding	RNA Polymerase III Activity DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding Ribonucleoside Binding
	Biological Process	Desmosome Assembly Heart Development Negative Regulation Of Cell Proliferation Positive Regulation Of Sodium Ion Transport Gap Junction Assembly Single Organismal Cell-cell Adhesion Negative Regulation Of Cell Migration Adherens Junction Maintenance Intermediate Filament Bundle Assembly Maintenance Of Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Lipid Homeostasis Cardiac Muscle Cell Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Tight Junction Assembly	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Defense Response To Virus
Pathways			RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: CTNNB1 DSC1 DSC2 DSG1 DSG2 DSP JUP KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A SMAD9 YWHAG	6 interactors: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E
Entrez ID		5318	11128
HPRD ID		04177	17879
Ensembl ID		ENSG00000057294	ENSG00000148606
Uniprot IDs		Q99959	O14802
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?		Bundle Of His Cell To Purkinje Myocyte Communication Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Muscle Contraction Cell Adhesion Regulation Of Heart Contraction Cellular Response To Indole-3-methanol Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Junction Organization Desmosome Organization Single Organismal Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Apoptotic Process Programmed Cell Death Adherens Junction Organization Regulation Of Membrane Potential Cell Death Death Regulation Of Cell Fate Specification Regulation Of Actin Filament-based Process Response To Organic Cyclic Compound Regulation Of Cell Fate Commitment Response To Organic Substance Skin Development Adherens Junction Assembly Cytoskeleton Organization Response To Progesterone Epidermis Development Centrosome Cycle Anatomical Structure Development Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Movement Golgi To Plasma Membrane CFTR Protein Transport Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Response To Stimulus Positive Regulation Of Type I Interferon Production	Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Type I Interferon Production Adherens Junction Maintenance Intracellular Receptor Signaling Pathway Transcription, DNA-templated Maintenance Of Organ Identity Heart Morphogenesis RNA Biosynthetic Process Intermediate Filament Bundle Assembly Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Response To Virus Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Desmosome Assembly Tetrahydrobiopterin Biosynthetic Process Regulation Of Tight Junction Assembly Immune Response Protein Targeting To Lysosome Cell Communication By Electrical Coupling Involved In Cardiac Conduction L-phenylalanine Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Desmosome Organization Positive Regulation Of Cytokine Production L-phenylalanine Metabolic Process Protein Localization To Lysosome Cell Communication By Electrical Coupling RNA Metabolic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Protein Homodimerization Activity Receptor Catabolic Process Ventricular Cardiac Muscle Cell Action Potential Gene Expression Protein Targeting To Vacuole Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Heart Rate By Cardiac Conduction Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Gap Junction Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Establishment Of Protein Localization To Vacuole
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp1 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside pabpc1 particles pkp1 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?