SERPINE2 and COL4A3

Number of citations of the paper that reports this interaction (PMID 8006028)
4

Data Source:
HPRD (in vivo)

		SERPINE2	COL4A3
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	collagen, type IV, alpha 3 (Goodpasture antigen)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Vesicle	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity
	Biological Process	Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Blood Circulation Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Glomerular Basement Membrane Development Endothelial Cell Apoptotic Process
Pathways		Common Pathway Intrinsic Pathway Dissolution of Fibrin Clot Formation of Fibrin Clot (Clotting Cascade)	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Height ( 20881960)	Corneal structure ( 23291589) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		9 interactors: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B PLAU	17 interactors: ANTXR2 APP CAMK2B CD93 COL4A3BP DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		5270	1285
HPRD ID		01510	00354
Ensembl ID		ENSG00000135919	ENSG00000169031
Uniprot IDs		P07093	Q01955
PDB IDs		4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Chemotaxis Locomotion Movement Of Cell Or Subcellular Component Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neuron Projection Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Nervous System Development Fibrinolysis Cell Development Neuromuscular Junction Development Renal System Development Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Glomerulus Development Cell Differentiation Negative Regulation Of Wound Healing Urogenital System Development Negative Regulation Of Angiogenesis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Blood Coagulation System Development Regulation Of Wound Healing Endothelial Cell Apoptotic Process Regulation Of Smooth Muscle Cell-matrix Adhesion Nephron Development Multicellular Organismal Development Synapse Organization	Extracellular Matrix Organization Extracellular Structure Organization System Development Immune System Process Response To Wounding Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Developmental Process Wound Healing Generation Of Neurons Cell Morphogenesis Nervous System Development Neurogenesis Cell Activation Cell Morphogenesis Involved In Differentiation Blood Coagulation Cell Differentiation Reproductive Process Hemostasis Response To Stress Platelet Activation Endodermal Cell Differentiation Acute-phase Response Regulation Of Meiosis Peptide Cross-linking Organ Development Leukocyte Migration Mating Regulation Of Body Fluid Levels Regulation Of Meiotic Cell Cycle Chemotaxis Endoderm Formation Response To Abiotic Stimulus Regulation Of Growth Seminal Vesicle Epithelium Development Dendrite Regeneration Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Cell Adhesion Tissue Development Neurological System Process Response To External Stimulus Cell Adhesion Platelet Degranulation Regulation Of Neurogenesis Acute Inflammatory Response Locomotion Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction
Tagcloud ?		adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight	alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Difference) ?		adulthood alters antagonize cerebellar cerebellum cgnp cgnps enlarged enlargement exit gli1 granular hedgehog interferes lobes lrps mitogenic morphogens nexin outer overactivation pn protease relies shaping shh sonic tight	alport amplified aras ascending audiological audiometric august autosomal certainly curves descending drop eighty exons fibroblast flat groove hearing impairment inheritance moderate oae recessive sensorineural sequenced sixteen wherein xlas
Tagcloud (Intersection) ?