PGM1 and USP4

Number of citations of the paper that reports this interaction (PMID 23022198)
1

Data Source:
BioGRID (two hybrid)

		PGM1	USP4
Gene Name		phosphoglucomutase 1	ubiquitin specific peptidase 4 (proto-oncogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Magnesium Ion Binding Phosphoglucomutase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glycogen Catabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Galactose Catabolic Process Small Molecule Metabolic Process	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Glucose metabolism Galactose catabolism Glycogen synthesis Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Type 1 diabetes ( 19430480)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		9 interactors: APP PAXIP1 POT1 S100A1 S100B TERF1 TERF2IP TINF2 USP4	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		5236	7375
HPRD ID		01389	04598
Ensembl ID		ENSG00000079739	ENSG00000114316
Uniprot IDs		B4DDQ8 B7Z6C2 P36871	Q08AK7 Q13107
PDB IDs			2Y6E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Assembly Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of DNA Replication Regulation Of Telomerase Activity Chromosome Organization DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome Homeostatic Process DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Recombination Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein ADP-ribosylation Positive Regulation Of Voltage-gated Calcium Channel Activity Synaptic Growth At Neuromuscular Junction	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		1p34 4q11 arm autosomal began c8 chromosome decade excluded familial fifth fourth fsp globulin linkage located location loci locus lod middle p36 paraplegia pure q13 rh slow spastic varied	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?		1p34 4q11 arm autosomal began c8 chromosome decade excluded familial fifth fourth fsp globulin linkage located location loci locus lod middle p36 paraplegia pure q13 rh slow spastic varied	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?