PFN2 and FAM173A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	FAM173A
Gene Name		profilin 2	family with sequence similarity 173, member A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome	Integral Component Of Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	9 interactors: BAG6 HAP1 IMMT KAT5 LUC7L LUC7L2 PFN2 SH3GL3 TP53
Entrez ID		5217	65990
HPRD ID		01451	14500
Ensembl ID		ENSG00000070087	ENSG00000103254
Uniprot IDs		G5E9Q6 P35080	J3KMW5 Q9BQD7
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly	Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Double-strand Break Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator MRNA Splice Site Selection Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Component Biogenesis Spliceosomal Complex Assembly Base-excision Repair Central Nervous System Development Chromosome Organization Positive Regulation Of Organelle Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Metabolic Process Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cerebellum Development Regulation Of Cell Projection Assembly Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Metencephalon Development Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Acetylation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cilium Assembly Negative Regulation Of Helicase Activity Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity DNA Repair Response To Ionizing Radiation Regulation Of Exocytosis Response To Endoplasmic Reticulum Stress Cellular Response To Stress Ribonucleoprotein Complex Assembly Hindbrain Development Positive Regulation Of Protein Complex Assembly Chromatin Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Ruffle Assembly Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Aging
Tagcloud ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?