PEX14 and ZHX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PEX14	ZHX1
Gene Name		peroxisomal biogenesis factor 14	zinc fingers and homeoboxes 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleolus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Protein Complex	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Receptor Binding Protein Binding Microtubule Binding Protein N-terminus Binding Beta-tubulin Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Complex Assembly Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of Protein Homotetramerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		8 interactors: HDAC1 MED8 NFE2 PEX19 PEX5 PEX7 SMARCC2 ZHX1	50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX
Entrez ID		5195	11244
HPRD ID		03477	10379
Ensembl ID		ENSG00000142655	ENSG00000165156
Uniprot IDs		F5H4J2 O75381	Q9UKY1
PDB IDs		2W84 2W85	2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Protein Import Into Peroxisome Membrane Peroxisomal Membrane Transport Protein Import Into Peroxisome Matrix Nucleosome Disassembly Protein Import Fatty Acid Beta-oxidation Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process ATP-dependent Chromatin Remodeling Protein Targeting Negative Regulation Of Lipid Binding Transcription, DNA-templated RNA Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Nucleosome Organization Cellular Lipid Catabolic Process Chromatin Assembly Or Disassembly Cellular Metabolic Process Cytoplasmic Transport Organ Development Protein Targeting To Membrane Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Matrix, Docking Neuron Migration Biosynthetic Process Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Lipid Modification Carboxylic Acid Catabolic Process Negative Regulation Of Protein Homooligomerization Ether Lipid Biosynthetic Process Protein Complex Disassembly Central Nervous System Neuron Differentiation Cell Differentiation	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex3 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Difference) ?		aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex11 pex28 pex3 pex5 pex6 pex7 pex8 pox1 puf5 rbp rfp	199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc
Tagcloud (Intersection) ?