C14orf166 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		C14orf166	GLP1R
Gene Name		chromosome 14 open reading frame 166	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm TRNA-splicing Ligase Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Binding RNA Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Transport	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DISC1 FAM98A GLP1R NIN	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		51637	2740
HPRD ID		16615	00677
Ensembl ID		ENSG00000087302	ENSG00000112164
Uniprot IDs		Q549M8 Q9Y224	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Centrosome-templated Microtubule Nucleation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Cellular Metal Ion Homeostasis Microtubule Cytoskeleton Organization Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Mitochondrial Calcium Ion Homeostasis Regulation Of Synapse Maturation Microtubule Nucleation Cellular Homeostasis TOR Signaling CAMP-mediated Signaling Microtubule-based Process Microtubule Polymerization Positive Regulation Of Neuroblast Proliferation Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Chemical Homeostasis Centrosome Localization Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Microtubule Polymerization Or Depolymerization Positive Regulation Of Lyase Activity Cell Proliferation In Forebrain Microtubule Anchoring Cytoskeleton Organization Response To Glucagon Regulation Of Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Stem Cell Proliferation Cellular Protein Localization Homeostatic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of Synapse Organization Cerebral Cortex Cell Migration Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		arch archaea archease asw c22orf28 c2orf49 cgi cooperation d10wsu52e ddx1 dead eukaryotes faap fam98b guanylate helicase hspc117 implies interplay ligase ligases ligation multimeric orthologous rtcb splicing trna trnas zbtb8os	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		arch archaea archease asw c22orf28 c2orf49 cgi cooperation d10wsu52e ddx1 dead eukaryotes faap fam98b guanylate helicase hspc117 implies interplay ligase ligases ligation multimeric orthologous rtcb splicing trna trnas zbtb8os	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?