CHMP5 and CHMP4B

Number of citations of the paper that reports this interaction (PMID 16730941)
46

Data Source:
HPRD (two hybrid)

		CHMP5	CHMP4B
Gene Name		charged multivesicular body protein 5	charged multivesicular body protein 4B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Endosome Membrane Extracellular Vesicular Exosome	ESCRT III Complex Nucleus Cytoplasm Endosome Cytosol Cytoplasmic Side Of Plasma Membrane Midbody Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Separation After Cytokinesis Regulation Of Receptor Recycling Nucleus Organization Lysosome Organization Mitotic Metaphase Plate Congression Endosome To Lysosome Transport Regulation Of Centrosome Duplication Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization Regulation Of Mitotic Spindle Assembly	Cell Separation After Cytokinesis Posttranslational Protein Targeting To Membrane Nucleus Organization Vacuolar Transport Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Viral Process Endosomal Transport Viral Life Cycle Maintenance Of Lens Transparency Viral Budding Via Host ESCRT Complex Viral Budding Regulation Of Viral Process Protein Homooligomerization Negative Regulation Of Cell Death Membrane Organization Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Neuron Death Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Autophagic Vacuole Assembly
Pathways		HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Erectile dysfunction and prostate cancer treatment ( 20932654)	Stearic acid (18:0) plasma levels ( 23362303)
Protein-Protein Interactions		15 interactors: APPBP2 CHMP1B CHMP4A CHMP4B GTF3A MITD1 PDCD10 RPL38 SMARCA4 STAMBP URGCP VPS4B VTA1 ZNF142 ZNF91	14 interactors: CHMP1B CHMP3 CHMP4A CHMP4C CHMP5 CHMP6 EXOSC9 HIPK2 PDCD6IP PIAS2 PTPN23 STAMBP UBE2I VPS4A
Entrez ID		51510	128866
HPRD ID		15408	16642
Ensembl ID		ENSG00000086065	ENSG00000101421
Uniprot IDs		Q9NZZ3	Q9H444
PDB IDs		2LXM 3ULY 3UM0 3UM1 3UM2	3C3Q 3UM3 4ABM
Enriched GO Terms of Interacting Partners?		Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Metaphase Plate Congression Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Establishment Of Chromosome Localization Viral Budding Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization Viral Life Cycle Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Virion Assembly Nucleus Organization Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Organelle Localization Mitotic Cell Cycle Process Regulation Of Centrosome Duplication Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Centrosome Cycle Mitotic Cell Cycle Organelle Localization Endosomal Transport Cell Cycle Posttranslational Protein Targeting To Membrane Positive Regulation Of Viral Release From Host Cell Establishment Of Localization In Cell Protein Transport Chromosome Segregation Positive Regulation Of Viral Process Establishment Of Protein Localization Vacuolar Transport Viral Process Membrane Budding Intracellular Transport Cell Cycle Process Negative Regulation Of Macroautophagy Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Localization Mitotic Nuclear Division Cytokinesis Regulation Of Autophagic Vacuole Assembly Regulation Of Mitotic Nuclear Division Regulation Of Vacuole Organization Protein Localization To Endoplasmic Reticulum Protein Localization Regulation Of Viral Release From Host Cell Regulation Of Microtubule Cytoskeleton Organization	Cell Separation After Cytokinesis Cell Division Mitotic Metaphase Plate Congression Metaphase Plate Congression Establishment Of Chromosome Localization Nucleus Organization Vacuolar Transport Mitotic Sister Chromatid Segregation Viral Process Sister Chromatid Segregation Viral Life Cycle Chromosome Segregation Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Mitotic Nuclear Division Mitotic Cell Cycle Process Endosomal Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Protein Transport Viral Budding Regulation Of Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Regulation Of Spindle Assembly Establishment Of Protein Localization Cell Cycle Process Regulation Of Microtubule-based Process Regulation Of Mitotic Spindle Organization Organelle Localization Regulation Of Cell Cycle Process Protein Localization Membrane Organization Cell Cycle Virion Assembly Regulation Of Cell Cycle Regulation Of Cellular Component Organization Abscission Cellular Macromolecule Catabolic Process Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Viral Release From Host Cell Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Division Cellular Protein Catabolic Process Negative Regulation Of Cytokinesis Membrane Budding Organelle Organization
Tagcloud ?		associate avian beyond budding coactivator conjugation dimer e3 endosome escrt evolved fusions gag hexamer homologue inability interferes isg15 leukosis lip5 probable rescued retroviruses sarcoma scission sorting tsg101 ubiquitin vps4	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Difference) ?		associate avian beyond budding coactivator conjugation dimer e3 endosome escrt evolved fusions gag hexamer homologue inability interferes isg15 leukosis lip5 probable rescued retroviruses sarcoma scission sorting tsg101 ubiquitin vps4	aculeiform adcc arg58his beaded bfsp1 bfsp2 cataract cerulean connexins coralliform cryaa cryba2 cryba4 crybb1 crybb3 cryga crygb crygc crygd crygs crystallins fasciculiform flaky gja3 gja8 lim2 macedonia pro23thr tmem114
Tagcloud (Intersection) ?