CDK16 and YWHAE

Number of citations of the paper that reports this interaction (PMID 12154078)
9

Data Source:
HPRD (in vivo)

		CDK16	YWHAE
Gene Name		cyclin-dependent kinase 16	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Synaptic Vesicle Microtubule Cytoskeleton Cell Junction Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection	Mitochondrion Cytosol Kinesin Complex Focal Adhesion Membrane Axon Cytoplasmic Vesicle Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Histone Deacetylase Binding Ion Channel Binding Poly(A) RNA Binding Protein Heterodimerization Activity Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Protein Phosphorylation Exocytosis Spermatogenesis Growth Hormone Secretion Neuron Projection Development Regulation Of Cell Cycle Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Apoptotic Process Organelle Organization Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways			HSF1 activation Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane G2/M Transition Activation of BH3-only proteins Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Programmed Cell Death Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Assembly of the primary cilium Cellular response to heat stress Regulation of HSF1-mediated heat shock response Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Signaling by Hippo Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation NADE modulates death signalling Mitotic G2-G2/M phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP APPBP2 ATRIP BAG6 BRCA1 CDK5 CDK5R1 PRKACA S100A10 SEC23A YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	107 interactors: ABL1 ACD AKAP13 ANKHD1-EIF4EBP3 ARHGEF2 ARHGEF28 ATXN1 BAD BCR CALM1 CAP2 CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP95 CGNL1 CHAF1A COX2 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GTF2B HDAC4 HDAC5 HIVEP2 HSF1 IGF1R IL7R ING1 IRS1 IRS2 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KRT18 LRMP MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MDM4 MSL2 MST1R MYH10 NCOR2 NDEL1 NGFRAP1 PAPOLA PNLIP POT1 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 REM1 RGS3 RIN1 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SNCA SORBS2 SRC SSFA2 SYN2 TAF7 TAZ TBC1D3F TBP TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF839
Entrez ID		5127	7531
HPRD ID		02409	05457
Ensembl ID		ENSG00000102225	ENSG00000108953
Uniprot IDs		B7Z8T0 Q00536 Q9BRL4	P62258
PDB IDs		3MTL	2BR9 3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Cell Death Death Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Cellular Protein Localization Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Transport Regulation Of Protein Localization Cellular Localization Intracellular Protein Transport Neural Nucleus Development Positive Regulation Of Apoptotic Process Protein Localization Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Death Regulation Of Cellular Localization Intracellular Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Brain Development Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Head Development Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Metabolic Process Protein Transport Establishment Of Localization In Cell Central Nervous System Development Substantia Nigra Development Peptidyl-threonine Phosphorylation Serine Phosphorylation Of STAT3 Protein Nervous System Development Transport	Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor System Development Neurotrophin TRK Receptor Signaling Pathway Developmental Process Neurotrophin Signaling Pathway Negative Regulation Of Phosphorylation Response To Organic Substance Anatomical Structure Development Multicellular Organismal Development Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Programmed Cell Death Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Organonitrogen Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		analyze animal ccnd1 ccni ccni2 cdk18 cdk3 cdk4 cdk8 cdk9 cdkis cdkn1a cdkn2a cdks comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Difference) ?		analyze animal ccnd1 ccni ccni2 cdk18 cdk3 cdk4 cdk8 cdk9 cdkis cdkn1a cdkn2a cdks comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Intersection) ?