MLXIPL and NIF3L1

Number of citations of the paper that reports this interaction (PMID 15163635)
19

Data Source:
HPRD (in vivo, two hybrid)

		MLXIPL	NIF3L1
Gene Name		MLX interacting protein-like	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Cytoplasm Mitochondrion
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity	GTP Cyclohydrolase I Activity Protein Binding GTP Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Cell Cycle Arrest Cellular Response To Carbohydrate Stimulus Negative Regulation Of Oxidative Phosphorylation Regulation Of Energy Homeostasis	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Transcription, DNA-templated
Pathways		PP2A-mediated dephosphorylation of key metabolic factors Integration of energy metabolism ChREBP activates metabolic gene expression PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Metabolic syndrome ( 22399527) Triglycerides ( 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20686565) Urate levels ( 23263486)
Protein-Protein Interactions		3 interactors: GRB2 MLX NIF3L1	64 interactors: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FAM49B FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1
Entrez ID		51085	60491
HPRD ID		12033	10424
Ensembl ID		ENSG00000009950	ENSG00000196290
Uniprot IDs		Q9NP71	Q9GZT8
PDB IDs
Enriched GO Terms of Interacting Partners?		7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Dihydrobiopterin Metabolic Process	Protein Oligomerization Nucleobase-containing Compound Metabolic Process Protein Tetramerization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nitrogen Compound Metabolic Process Nucleoside Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Protein Complex Assembly Protein Homotetramerization Purine Nucleoside Metabolic Process Protein Homooligomerization Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Metabolic Process Polyamine Catabolic Process Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination Nucleotide Metabolic Process Amine Metabolic Process Ribonucleotide Metabolic Process Biosynthetic Process Cellular Metabolic Process Purine Nucleotide Metabolic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity Cellular Component Assembly Sulfation Sulfur Compound Metabolic Process Positive Regulation Of T Cell Activation Gene Expression Amine Biosynthetic Process Oocyte Maturation Positive Regulation Of Homotypic Cell-cell Adhesion Transcription, DNA-templated Regulation Of Glycolytic Process Meiosis I Organophosphate Metabolic Process Male Meiosis I Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell-cell Adhesion RNA Biosynthetic Process Response To Injury Involved In Regulation Of Muscle Adaptation Deoxyhypusine Biosynthetic Process From Spermidine Glucose Mediated Signaling Pathway Polyamine Homeostasis Response To Brefeldin A
Tagcloud ?		adipogenic adipokines calving cebpa cebpb chrebp crebbp dgat2 fo hydroxybutyrate lcfa lipogenesis lipogenic lpin1 med1 ncoa1 ncor2 nfkb1 nonesterified nrip1 parturition peripartal postpartal prepartal prepartum rxra scd sfat triacylglycerol
Tagcloud (Difference) ?		adipogenic adipokines calving cebpa cebpb chrebp crebbp dgat2 fo hydroxybutyrate lcfa lipogenesis lipogenic lpin1 med1 ncoa1 ncor2 nfkb1 nonesterified nrip1 parturition peripartal postpartal prepartal prepartum rxra scd sfat triacylglycerol
Tagcloud (Intersection) ?