PARN and MAPKAPK2

Number of citations of the paper that reports this interaction (PMID 20932473)
36

Data Source:
BioGRID (enzymatic study)

		PARN	MAPKAPK2
Gene Name		poly(A)-specific ribonuclease	mitogen-activated protein kinase-activated protein kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Poly(A) RNA Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Female Gamete Generation RNA Modification Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Leukotriene Metabolic Process Response To Stress Inflammatory Response Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Gene Expression Peptidyl-serine Phosphorylation Arachidonic Acid Metabolic Process G2 DNA Damage Checkpoint Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inner Ear Development Stress-activated MAPK Cascade 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA KSRP destabilizes mRNA ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay	Signalling to ERKs CREB phosphorylation Metabolism of lipids and lipoproteins Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Arachidonic acid metabolism Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signalling by NGF Regulation of mRNA stability by proteins that bind AU-rich elements MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Regulation of HSF1-mediated heat shock response Synthesis of Leukotrienes (LT) and Eoxins (EX) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs			Staurosporine Adenosine-5\'-Diphosphate 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5\',6\':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: KHSRP MAPKAPK2 MPHOSPH6 MPP6 SPATC1L	32 interactors: AKT1 ALOX5 ARPC5 BAG2 CDC25B CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK1 MAPK14 MAPK3 PABPC1 PARN PHC2 PIAS2 SHC1 SRF TCF3 TH TSC2 UBE2J1 YWHAZ ZFP36 ZFP36L1
Entrez ID		5073	9261
HPRD ID		07250	11882
Ensembl ID		ENSG00000140694	ENSG00000162889
Uniprot IDs		B3KN69 B4DSB0 O95453	P49137
PDB IDs		2A1R 2A1S 3CTR	1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Macropinocytosis Ribonucleoprotein Complex Biogenesis Regulation Of MiRNA Metabolic Process 3'-UTR-mediated MRNA Stabilization	Positive Regulation Of Macromolecule Biosynthetic Process Response To External Stimulus Defense Response Platelet Activation Posttranscriptional Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gene Expression Fc Receptor Signaling Pathway Positive Regulation Of Gene Expression Response To Stress Regulation Of MRNA Stability Response To Peptide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cell Activation Regulation Of RNA Stability Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Neurotrophin Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels MRNA Stabilization Insulin Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Transcription, DNA-templated Innate Immune Response Chemotaxis Response To Growth Factor Blood Coagulation Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Hemostasis ERBB Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Peptide Hormone
Tagcloud ?		ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr	cot densitometry erk2 hog immunoreactivities jnks kinases mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		ags arrested bulk deadenylases deadenylation decay deciphered depletion dissimilar g0 gastric heterogeneity knocking limiting mkn28 motility mrnas p21 p27 relied ribonuclease silence stability stabilizing stably triggered unaffected upregulating utr	cot densitometry erk2 hog immunoreactivities jnks kinases mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?