PAK3 and ARHGEF6

Number of citations of the paper that reports this interaction (PMID 9659915)
169

Data Source:
HPRD (in vivo)

		PAK3	ARHGEF6
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 3	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane	Intracellular Cytosol Cell-cell Junction Lamellipodium
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding Metal Ion Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Protein Phosphorylation Axonogenesis Axon Guidance Dendrite Development Signal Transduction By Phosphorylation Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of DNA Biosynthetic Process	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Generation of second messenger molecules Costimulation by the CD28 family Axon guidance Semaphorin interactions CD28 co-stimulation FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway CD28 dependent Vav1 pathway Ephrin signaling TCR signaling Activation of Rac Signaling by VEGF VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion Signaling by Robo receptor Innate Immune System Adaptive Immune System	Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 SNCA SYN1	22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580
Entrez ID		5063	9459
HPRD ID		02142	02226
Ensembl ID		ENSG00000077264	ENSG00000129675
Uniprot IDs		B2RCU6 O75914	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Lamellipodium Assembly Lamellipodium Organization Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Assembly Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Neuron Projection Development Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Ephrin Receptor Signaling Pathway Axon Development Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Chemotaxis Cell Morphogenesis Positive Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Neuron Differentiation Regulation Of Protein Complex Assembly Cell Development Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Component Assembly Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Kinase Activity Cell-cell Junction Organization Regulation Of Cell Death	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?