ORC2 and MCM6

Number of citations of the paper that reports this interaction (PMID 12614612)
16

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		ORC2	MCM6
Gene Name		origin recognition complex, subunit 2	minichromosome maintenance complex component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Plasma Membrane Membrane	Nucleus Nucleoplasm MCM Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: CDC45 CDC5L CDC6 CDK2 CDT1 DBF4 HIST3H3 HIST4H4 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 XRCC5	31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9
Entrez ID		4999	4175
HPRD ID		03112	03485
Ensembl ID			ENSG00000076003
Uniprot IDs		Q13416	Q14566
PDB IDs			2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process Mitotic Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Process DNA Replication Initiation Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Duplex Unwinding DNA Geometric Change Chromosome Organization Biosynthetic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Organelle Organization Cell Cycle Checkpoint DNA Replication Checkpoint Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Recombinase Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Double-strand Break Repair DNA Repair Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress DNA Recombination Nucleotide-excision Repair, DNA Gap Filling	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle
Tagcloud ?		brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		brdu budding catalytic comprising discs dpolepsilon dpolepsilonp255 dpolepsilonp58 drosophila endoreplication epsilon eye hetero homozygous imaginal instar kda larvae lethal multicellular organism ph3 polepsilon pupal replicating salivary stop strand tetrameric	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?