NRF1 and PPRC1

Number of citations of the paper that reports this interaction (PMID 11340167)
76

Data Source:
HPRD (in vivo, in vitro)

		NRF1	PPRC1
Gene Name		nuclear respiratory factor 1	peroxisome proliferator-activated receptor gamma, coactivator-related 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity Transcription Factor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Organ Regeneration Response To Estradiol Response To Lipopolysaccharide Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Folic Acid Response To Electrical Stimulus	Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CSNK2A1 DYNLL1 FHL2 MAFF PARP1 POGZ PPARGC1A PPRC1 SP4 TRAF2	3 interactors: NRF1 USF1 USF2
Entrez ID		4899	23082
HPRD ID		02930	15173
Ensembl ID		ENSG00000106459	ENSG00000148840
Uniprot IDs		Q16656 Q96AN2	E7EVG6 Q5VV67
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Reactive Nitrogen Species Nucleobase-containing Compound Metabolic Process Cellular Response To Oxidative Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Nitrite Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Death Response To Oxidative Stress Regulation Of Mitochondrion Organization Cellular Response To Tumor Necrosis Factor Cellular Response To Reactive Oxygen Species Response To Inorganic Substance Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Binding Response To Tumor Necrosis Factor Protein Poly-ADP-ribosylation Atrial Cardiac Muscle Cell Development Positive Regulation Of Energy Homeostasis Response To Statin Regulation Of Growth Rate	Late Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Response To Nutrient Response To Nutrient Levels Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Response To Extracellular Stimulus Cellular Response To Nutrient Viral Transcription Transcription From RNA Polymerase II Promoter Lipid Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Nutrient Levels Positive Regulation Of Transcription, DNA-templated Viral Life Cycle Homeostatic Process Cellular Response To Extracellular Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Hypoxia Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Cellular Metabolic Process Viral Process Response To Folic Acid Regulation Of Fibrinolysis RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Heme Biosynthetic Process Response To Organonitrogen Compound Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chemical Homeostasis Positive Regulation Of Blood Coagulation Porphyrin-containing Compound Biosynthetic Process Response To Hormone Positive Regulation Of Coagulation Heme Metabolic Process Response To Electrical Stimulus Positive Regulation Of Wound Healing Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus
Tagcloud ?		architectural architecture bach bach1 bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nucleoprotein obligate opening poz properly zipper
Tagcloud (Difference) ?		architectural architecture bach bach1 bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nucleoprotein obligate opening poz properly zipper
Tagcloud (Intersection) ?