NPHS1 and NPHS2

Number of citations of the paper that reports this interaction (PMID 11733557)
86

Data Source:
HPRD (in vivo, in vitro)

		NPHS1	NPHS2
Gene Name		nephrosis 1, congenital, Finnish type (nephrin)	nephrosis 2, idiopathic, steroid-resistant (podocin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Slit Diaphragm Cell Projection Protein Complex Membrane Raft Extracellular Vesicular Exosome	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Slit Diaphragm Protein Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Myosin Binding Protein Domain Specific Binding Spectrin Binding Alpha-actinin Binding	Protein Binding
	Biological Process	Cell Adhesion JNK Cascade Skeletal Muscle Tissue Development Myoblast Fusion Excretion Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Regulation Of Excretion Glomerular Visceral Epithelial Cell Development	Excretion Actin Cytoskeleton Reorganization Metanephric Glomerular Visceral Epithelial Cell Development
Pathways			Nephrin interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASK CD2AP FYN IQGAP1 KIRREL LYN NCK1 NCK2 NPHS2 SRC YES1	4 interactors: CD2AP KIRREL KIRREL3 NPHS1
Entrez ID		4868	7827
HPRD ID		04094	05303
Ensembl ID		ENSG00000161270	ENSG00000116218
Uniprot IDs		O60500	Q9NP85
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ephrin Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Axon Guidance Regulation Of Lymphocyte Activation Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Activation Signal Complex Assembly Cell Motility Enzyme Linked Receptor Protein Signaling Pathway T Cell Costimulation Neuron Development Axonogenesis Phagocytosis Axon Development Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Chemotaxis Neuron Differentiation Cell Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Morphogenesis Involved In Differentiation Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Complex Assembly Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation	Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Excretion Regulation Of Cytoskeleton Organization Glomerulus Development Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Nephron Development Regulation Of Organelle Organization Positive Regulation Of Protein Complex Assembly Principal Sensory Nucleus Of Trigeminal Nerve Development Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Inter-male Aggressive Behavior Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta Production Kidney Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Renal System Development Regulation Of Protein Complex Assembly Urogenital System Development Glomerular Visceral Epithelial Cell Development Positive Regulation Of Organelle Organization Substrate-dependent Cell Migration, Cell Extension Aggressive Behavior Regulation Of Cellular Component Organization Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Glomerulus Morphogenesis Myoblast Fusion Regulation Of Excretion Syncytium Formation Substrate-dependent Cell Migration Regulation Of Actin Cytoskeleton Reorganization Cell Differentiation Involved In Kidney Development Cell Migration Cell Motility Neural Nucleus Development Myotube Differentiation Cell Projection Organization Cell Adhesion JNK Cascade Locomotion Positive Regulation Of Protein Localization To Nucleus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade
Tagcloud ?		1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate	11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease glomerulosclerosis han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic segmental srns t560a
Tagcloud (Difference) ?		1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter specialized terminally tnfalpha translocate	11t 13c 1678a 181g 279t 35a 38g 48t 718c 86t biotechnology boundaries d93d endonuclease han ivs1 ivs16 ivs18 ivs19 ivs2 ivs25 ivs6 l240f myo1e nephrotic srns t560a
Tagcloud (Intersection) ?		glomerulosclerosis segmental