NOS1 and RASD1

Number of citations of the paper that reports this interaction (PMID 11086993)
65

Data Source:
HPRD (in vivo)

		NOS1	RASD1
Gene Name		nitric oxide synthase 1 (neuronal)	RAS, dexamethasone-induced 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol Cytoskeleton Sarcoplasmic Reticulum Sarcolemma Dendritic Spine Protein Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Ryanodine Receptor Complex	Nucleus Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	GTPase Activity GTP Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Coagulation Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Phagosome Maturation Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current	Signal Transduction G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Small GTPase Mediated Signal Transduction Negative Regulation Of Transcription, DNA-templated
Pathways		Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N\'-Hydroxyguanidine N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin N-Butyl-N\'-Hydroxyguanidine Alpha-D-Mannose S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Heme N-Omega-Hydroxy-L-Arginine Flavin-Adenine Dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2\'-Monophosphoadenosine 5\'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		33 interactors: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PTPN6 PTPRN RASD1 SNTA1 STUB1 SUMO1 SYN1 VAC14 ZDHHC23	10 interactors: GNAI1 GNAI2 GNB1 HNRNPK MATR3 NOS1 NOS1AP PLSCR1 RBMY1F TRIM37
Entrez ID		4842	51655
HPRD ID		01226	08958
Ensembl ID		ENSG00000089250	ENSG00000108551
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	Q9Y272
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling Regulation Of Catalytic Activity Regulation Of Ion Transport Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Signaling Regulation Of Striated Muscle Contraction Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Regulation Of Cellular Localization Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Chemical Homeostasis Regulation Of Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metal Ion Homeostasis Synaptic Transmission Regulation Of Oxidoreductase Activity Regulation Of Phosphorylation Activation Of Adenylate Cyclase Activity Cellular Response To Stimulus Cellular Cation Homeostasis Homeostatic Process Cellular Calcium Ion Homeostasis Vasoconstriction Cellular Ion Homeostasis Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Signal Transduction Cytosolic Calcium Ion Homeostasis Cellular Localization Metal Ion Homeostasis Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport	Blood Coagulation Hemostasis Platelet Activation Regulation Of Generation Of L-type Calcium Current Regulation Of Body Fluid Levels Wound Healing Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Calcium Ion Transport Cell Activation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Negative Regulation Of Serotonin Uptake Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Histone H2A-K119 Monoubiquitination Synaptic Transmission Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Heart Contraction Regulation Of Signal Transduction Peptidyl-cysteine S-nitrosylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transport Negative Regulation Of Centriole Replication Regulation Of Adrenergic Receptor Signaling Pathway Phosphatidylserine Biosynthetic Process
Tagcloud ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	aci bcl behind carcinogenesis chemoprevention chemopreventive develops dysregulated dysregulation e2 ellagic eralpha examining foxo1 foxo3a insights mammary mechanistic mir mirna mirnas modulated persisted reversed reversing signature systematic tumorigenesis w
Tagcloud (Difference) ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	aci bcl behind carcinogenesis chemoprevention chemopreventive develops dysregulated dysregulation e2 ellagic eralpha examining foxo1 foxo3a insights mammary mechanistic mir mirna mirnas modulated persisted reversed reversing signature systematic tumorigenesis w
Tagcloud (Intersection) ?