NFKBIB and LRPPRC

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		NFKBIB	LRPPRC
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	leucine-rich pentatricopeptide repeat containing
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Mitochondrion Cytoskeleton Microtubule Membrane Ribonucleoprotein Complex Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Signal Transducer Activity Protein Binding	Single-stranded DNA Binding RNA Binding Protein Binding Microtubule Binding Poly(A) RNA Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide	Negative Regulation Of Mitochondrial RNA Catabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation
Pathways		Signaling by the B Cell Receptor (BCR) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: APP BAK1 BTRC CD3EAP CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	7 interactors: CECR2 FOXO1 HEBP2 MAP1S NFKBIB PPARGC1A UXT
Entrez ID		4793	10128
HPRD ID		07260	06343
Ensembl ID		ENSG00000104825	ENSG00000138095
Uniprot IDs		Q15653	E5KNY5 P42704
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Positive Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Regulation Of Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response	Regulation Of Energy Homeostasis Mitochondrion Transport Along Microtubule Establishment Of Mitochondrion Localization Positive Regulation Of Gluconeogenesis Apoptotic DNA Fragmentation Cellular Response To Reactive Nitrogen Species Temperature Homeostasis Apoptotic Nuclear Changes Positive Regulation Of Glucose Metabolic Process Mitochondrion Localization Regulation Of Gluconeogenesis Organelle Transport Along Microtubule Response To Cold Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Nitrite DNA Catabolic Process, Endonucleolytic Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Fat Cell Differentiation Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Microtubule-based Transport Organelle Organization Cytoskeleton-dependent Intracellular Transport DNA Catabolic Process Cellular Response To Inorganic Substance Regulation Of Carbohydrate Metabolic Process Response To Statin Positive Regulation Of Energy Homeostasis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Respiration Response To Starvation Response To Temperature Stimulus Negative Regulation Of Mitochondrial Membrane Potential Cellular Response To Oxidative Stress Transcription From RNA Polymerase II Promoter Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Response To Norepinephrine Cellular Response To Cold Response To Leucine Multicellular Organismal Homeostasis Apoptotic Process
Tagcloud ?		abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 pca periodicals survive vary wildtype wiley
Tagcloud (Difference) ?		abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing	adenocarcinomas autophagic autophagosomal autophagy biogenesis bridges c19orf5 collaboration collaboratively diethylnitrosamine guangzhou h2ax hepatocelular immunochemical inc map1a map1b map1s microtubules mitochondrion named originally p62 pca periodicals survive vary wildtype wiley
Tagcloud (Intersection) ?