RERE and ALG13

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RERE	ALG13
Gene Name		arginine-glutamic acid dipeptide (RE) repeats	ALG13, UDP-N-acetylglucosaminyltransferase subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus	Endoplasmic Reticulum Membrane
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Poly-glutamine Tract Binding Zinc Ion Binding Sequence-specific DNA Binding	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Peptidase Activity Carbohydrate Binding Poly(A) RNA Binding
	Biological Process	Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated NLS-bearing Protein Import Into Nucleus Multicellular Organismal Development	Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis Protein N-linked Glycosylation Via Asparagine Lipid Glycosylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bone mineral density ( 22504420) Vertical cup-disc ratio ( 20548946) Vitiligo ( 20410501)
Protein-Protein Interactions		20 interactors: ALG13 ATN1 CBFA2T2 ECM1 EFEMP1 EFEMP2 EHMT2 HIST2H3C KAT6A KRTAP4-12 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 TRIM22 TRIP6 ZMYND8	7 interactors: ATN1 ATXN1L HOXA1 MAPKBP1 PITX1 RBFOX1 RERE
Entrez ID		473	79868
HPRD ID		05566	06542
Ensembl ID		ENSG00000142599	ENSG00000101901
Uniprot IDs		B1AKN3 Q9P2R6	Q9NP73
PDB IDs		2YQK
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression DNA Methylation On Cytosine Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Transcription, DNA-templated RNA Biosynthetic Process Amygdala Development RNA Metabolic Process DNA Methylation Somatic Stem Cell Maintenance Response To Stress Negative Regulation Of Cell Differentiation Cellular Macromolecule Biosynthetic Process DNA Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity DNA Methylation On Cytosine Within A CG Sequence Blood Coagulation Hemostasis Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Angiogenesis Regulation Of Cell Differentiation Peptidyl-amino Acid Modification Phosphatidylserine Biosynthetic Process Regulation Of Timing Of Neuron Differentiation	RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Optokinetic Behavior Abducens Nerve Formation Cellular Macromolecule Biosynthetic Process Neuromuscular Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Facial Nucleus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation Branchiomeric Skeletal Muscle Development Semicircular Canal Formation Rhombomere 4 Development Rhombomere 3 Development Rhombomere 5 Development Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Central Nervous System Development Myoblast Fate Commitment Multicellular Organismal Development Regulation Of Hematopoietic Stem Cell Proliferation Biosynthetic Process Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Semicircular Canal Morphogenesis Rhombomere Development Maintenance Of Cell Polarity Facial Nerve Structural Organization Pons Development Facial Nerve Morphogenesis Developmental Process Toxin Metabolic Process Semicircular Canal Development Parasympathetic Nervous System Development NLS-bearing Protein Import Into Nucleus Anatomical Structure Arrangement Cellular Metabolic Process Cochlea Morphogenesis
Tagcloud ?		antagonism caudal downregulating e8 ectopic embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate	34a abcf2 adhesions bioinformatics chance ctcf fak held kaplan ki67 lyar meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr
Tagcloud (Difference) ?		antagonism caudal downregulating e8 ectopic embryos exiting extending fgf fgf8 fused h3k27me3 lacz mesoderm neuroectoderm polycomb prc2 ra raldh2 rarb rare rares repress represses repressive somite somites trunk vertebrate	34a abcf2 adhesions bioinformatics chance ctcf fak held kaplan ki67 lyar meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr
Tagcloud (Intersection) ?