NCBP1 and NCBP2

Number of citations of the paper that reports this interaction (PMID 12434151)
40

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NCBP1	NCBP2
Gene Name		nuclear cap binding protein subunit 1, 80kDa	nuclear cap binding protein subunit 2, 20kDa
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex
	Molecular Function	RNA Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding	Nucleotide Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Cleavage MRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Viral Transcription	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Viral Transcription
Pathways		mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation	mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		14 interactors: BNIP1 BNIP2 BNIP3 C17orf85 EIF4G1 EIF4G2 HNRNPF HNRNPH1 NCBP2 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17	7 interactors: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		4686	22916
HPRD ID		02717	05503
Ensembl ID		ENSG00000136937	ENSG00000114503
Uniprot IDs		Q09161	E9PAR5 P52298
PDB IDs		1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Regulation Of Translation RNA Splicing Posttranscriptional Regulation Of Gene Expression Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Viral Process MRNA 3'-end Processing Cellular Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Fusion SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Apoptotic Process Negative Regulation Of Cell Death RNA 3'-end Processing Positive Regulation By Virus Of Viral Protein Levels In Host Cell Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Protein Catabolic Process Programmed Cell Death Catabolic Process Cellular Metabolic Process Skeletal Muscle Atrophy Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Viral Process RNA Localization Insulin Receptor Signaling Pathway Autophagic Cell Death Striated Muscle Atrophy Response To Leucine Regulation Of Mitochondrial Fusion Regulation Of Viral Process MRNA Catabolic Process Cellular Response To Cobalt Ion Muscle Atrophy RNA Catabolic Process Skeletal Muscle Adaptation Histone H2B Ubiquitination	MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Translational Initiation RNA Splicing Nuclear Export Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Gene Expression MRNA Export From Nucleus RNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Viral Process RNA 3'-end Processing Regulation Of Gene Expression MRNA Transport Cellular Macromolecular Complex Assembly RNA Transport RNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Cytoplasmic Transport RNA Localization RNA Secondary Structure Unwinding MRNA Catabolic Process Ribonucleoprotein Complex Assembly Negative Regulation Of DNA Damage Checkpoint RNA Catabolic Process Translational Initiation Viral MRNA Export From Host Cell Nucleus Spindle Midzone Assembly Regulation Of DNA Damage Checkpoint Microtubule Severing Ribonucleoprotein Complex Biogenesis Nucleobase-containing Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA 3'-end Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MRNA 3'-end Processing Regulation Of Metabolic Process MRNA Cleavage Cellular Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Aromatic Compound Catabolic Process
Tagcloud ?		adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Difference) ?		adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Intersection) ?