NASP and HIST1H4A

Number of citations of the paper that reports this interaction (PMID 20167597)
12

Data Source:
BioGRID (pull down)

		NASP	HIST1H4A
Gene Name		nuclear autoantigenic sperm protein (histone-binding)	histone cluster 1, H4a
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein Complex	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Histone Binding Hsp90 Protein Binding	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Blastocyst Development DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Cell Cycle Cell Proliferation Protein Transport Histone Exchange	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			HIV-1 viral setpoint ( 22174851)
Protein-Protein Interactions		14 interactors: H3F3B H3F3C HDAC6 HIST1H1A HIST1H1C HIST1H3G HIST1H3H HIST1H4A HIST2H3C LUC7L2 PTK2 TERF2 TERF2IP ULK2	73 interactors: ANP32A BAZ1B BAZ2A BLOC1S1 BRD2 CALCOCO1 CBX3 CDK1 CDK2 COPS2 CREBBP CTDP1 DYRK1A EID1 ELP3 EP300 ERCC6 GATAD2A GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC8 HIRIP3 HIST1H3A HIST2H2AC HIST2H2BE HJURP KAT2A KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT2A L3MBTL2 MSL2 MSL3 NASP NCOR1 NCOR2 NPM1 NR1H4 PAK1 PARP1 PARP10 PBRM1 PELP1 PHF20 PHF8 PRMT1 PRMT5 PRMT7 PRMT8 PTMA RCC1 SETD7 SIRT7 SSRP1 SUV420H1 SUV420H2 TAF1 TAF1A TAF1B TBL1X THAP7 TP53BP1 UBC UBE2I UCHL5 YY1
Entrez ID		4678	8359
HPRD ID		04423	04157
Ensembl ID		ENSG00000132780	ENSG00000196176
Uniprot IDs		P49321 Q5T626	B2R4R0 P62805
PDB IDs			2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly DNA Methylation Protein-DNA Complex Assembly Negative Regulation Of Gene Expression, Epigenetic DNA Packaging Cellular Macromolecular Complex Assembly Chromosome Organization DNA Modification Regulation Of Gene Expression, Epigenetic Chromatin Organization Gene Silencing DNA Conformation Change Cellular Component Assembly DNA Replication-dependent Nucleosome Assembly Organelle Organization Protein Complex Assembly DNA Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Methylation Blood Coagulation Hemostasis Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Regulation Of Body Fluid Levels Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Wound Healing Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Response To Wounding Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Negative Regulation Of Gene Expression RNA-dependent DNA Replication Regulation Of Gene Silencing Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening DNA Replication-independent Nucleosome Assembly Gene Expression	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Regulation Of Metabolic Process Peptidyl-lysine Acetylation Peptidyl-amino Acid Modification Protein Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Histone Acetylation Negative Regulation Of RNA Biosynthetic Process Internal Peptidyl-lysine Acetylation Cellular Protein Modification Process Internal Protein Amino Acid Acetylation Negative Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Histone H4 Acetylation Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Chromatin Remodeling Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter
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