MYO10 and CALML3

Number of citations of the paper that reports this interaction (PMID 11278607)
14

Data Source:
HPRD (in vivo, two hybrid)

		MYO10	CALML3
Gene Name		myosin X	calmodulin-like 3
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body	Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin-dependent ATPase Activity Actin Filament Binding Plus-end Directed Microfilament Motor Activity	Calcium Ion Binding Protein Binding
	Biological Process	Axon Guidance Metabolic Process Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Filopodium Assembly
Pathways		Axon guidance Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		6 interactors: ACTA1 CALM1 CALML3 DYNLL1 ITGB5 PLA2G10	6 interactors: BHLHE40 C11orf65 KIAA1683 MAPK4 MYO10 TERF2IP
Entrez ID		4651	810
HPRD ID		03283	00244
Ensembl ID		ENSG00000145555	ENSG00000178363
Uniprot IDs		E7EPL7 Q9HD67	P27482
PDB IDs		2LW9 3AU4 3AU5 3PZD	1GGZ
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Substantia Nigra Development Neural Nucleus Development Midbrain Development Actin Cytoskeleton Organization Actin Filament-based Process Lysophospholipid Transport Actomyosin Structure Organization Positive Regulation Of Transport Multicellular Organismal Development Anatomical Structure Development Skeletal Muscle Fiber Adaptation Anatomical Structure Morphogenesis Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cholesterol Efflux Regulation Of High Voltage-gated Calcium Channel Activity Cytoskeleton Organization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Arachidonic Acid Secretion Skeletal Muscle Thin Filament Assembly Organelle Organization Antigen Processing And Presentation Regulation Of Arachidonic Acid Secretion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Actin Filament Organization Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Alcohol Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Cholesterol Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphatidylinositol Acyl-chain Remodeling Positive Regulation Of Prostaglandin Secretion Stress Fiber Assembly Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Regulation Of Intracellular Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion	Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomere Maintenance RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA Recombination Photoperiodism Entrainment Of Circadian Clock Regulation Of Double-strand Break Repair
Tagcloud ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	actinic attractive correlates differentiating downregulated embedded epidermis exhibiting granulosum hyperplastic hyperproliferative immunoreactivity inversely keratinocyte keratinocytes keratosis ki layers localization marker paraffin periphery postmitotic psoriasis stratum suprabasal transformed verruca
Tagcloud (Difference) ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	actinic attractive correlates differentiating downregulated embedded epidermis exhibiting granulosum hyperplastic hyperproliferative immunoreactivity inversely keratinocyte keratinocytes keratosis ki layers localization marker paraffin periphery postmitotic psoriasis stratum suprabasal transformed verruca
Tagcloud (Intersection) ?