MYLK and CTTN

Number of citations of the paper that reports this interaction (PMID 12408982)
29

Data Source:
HPRD (in vitro)

		MYLK	CTTN
Gene Name		myosin light chain kinase	cortactin
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cell-cell Junction Lamellipodium Cleavage Furrow Extracellular Vesicular Exosome	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone
	Molecular Function	Actin Binding Calmodulin-dependent Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Actin Filament Organization Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Positive Regulation Of Wound Healing	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACTA1 ACTC1 CALM1 CAMK2G CTTN GOPC MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC	36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1
Entrez ID		4638	2017
HPRD ID		02952	01268
Ensembl ID		ENSG00000065534	ENSG00000085733
Uniprot IDs		B4DUE3 Q15746 Q6P2N0	Q14247 Q53HG7
PDB IDs		2CQV 2K0F 2YR3	1X69 2D1X
Enriched GO Terms of Interacting Partners?		Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Innate Immune Response Fc Receptor Signaling Pathway Wound Healing Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Response To Abiotic Stimulus Actin Filament-based Process Actin-myosin Filament Sliding Muscle Filament Sliding Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Response To Wounding Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cellular Component Assembly Epidermal Growth Factor Receptor Signaling Pathway Anatomical Structure Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Actin-mediated Cell Contraction Immune Response Regulation Of Kinase Activity Protein Phosphorylation Blood Coagulation Hemostasis Defense Response Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Peptidyl-serine Autophosphorylation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Muscle Contraction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization
Tagcloud ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?