MYH10 and PBX1

Number of citations of the paper that reports this interaction (PMID 12724421)
14

Data Source:
HPRD (in vivo, two hybrid)

		MYH10	PBX1
Gene Name		myosin, heavy chain 10, non-muscle	pre-B-cell leukemia homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Mitochondrion Spindle Plasma Membrane Cell Cortex Actin Cytoskeleton Myosin Complex Myosin II Complex Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Actomyosin Neuronal Cell Body Dendritic Spine Extracellular Vesicular Exosome Myosin II Filament	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axon Guidance Adult Heart Development Cell Proliferation Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Filament-based Movement Actomyosin Structure Organization Ephrin Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Retina Development In Camera-type Eye	Branching Involved In Ureteric Bud Morphogenesis Transcription, DNA-templated Steroid Biosynthetic Process Sex Differentiation Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Ossification Adrenal Gland Development Embryonic Limb Morphogenesis Somatic Stem Cell Maintenance Embryonic Hemopoiesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Thymus Development Embryonic Skeletal System Development
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS			Breast cancer (prognosis) ( 23319801) Height ( 20966902)
Protein-Protein Interactions		9 interactors: APC BCAP31 KIAA0368 MYH9 PBX1 S100A4 YWHAE YWHAG ZNF512B	24 interactors: CREBBP HOXA1 HOXA10 HOXA5 HOXA9 HOXB1 HOXB7 HOXB8 HOXD10 HOXD4 HOXD9 KAT2A MDM2 MEIS1 MEIS2 MYH10 NEDD4L NR3C1 PAX6 PBX2 PDX1 PKNOX1 POU2F1 SMARCD3
Entrez ID		4628	5087
HPRD ID		01178	08889
Ensembl ID		ENSG00000133026	ENSG00000185630
Uniprot IDs		B2RWP9 G1UI33 P35580 Q9BWG0	A8K5V0 H0YLB0 P40424 Q53YC7
PDB IDs			1B72 1PUF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Stem Cell Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proximal/distal Pattern Formation Generation Of Neurons Regulation Of Signal Transduction Neurogenesis Thymus Development Stem Cell Differentiation Positive Regulation Of Mitochondrion Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signaling Somatic Stem Cell Maintenance Apoptotic Process Programmed Cell Death Execution Phase Of Apoptosis Cell Cycle Process Positive Regulation Of Organelle Organization Cell Death Death Cell Differentiation Regulation Of Mitochondrion Organization Cytokinesis Nervous System Development Regulation Of Heart Rate By Hormone Negative Regulation Of Peptidyl-serine Dephosphorylation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Transport Hemopoiesis Regulation Of Apoptotic Process Establishment Of Protein Localization Stem Cell Maintenance Negative Regulation Of Odontogenesis System Development Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cell Death Uropod Organization Establishment Of Meiotic Spindle Localization	Transcription, DNA-templated RNA Biosynthetic Process Embryonic Morphogenesis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Pattern Specification Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anterior/posterior Pattern Specification Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Developmental Process Organ Morphogenesis Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Anatomical Structure Development Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Skeletal System Development System Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Skeletal System Morphogenesis Embryonic Limb Morphogenesis Embryonic Organ Development Negative Regulation Of Myeloid Cell Differentiation
Tagcloud ?		accordance aorta arteries atherosclerosis carotid ciclin d2 expresses functionality hemodynamic hyperplasia immunocitochemistry immunostaining intima labelling ligated ligation modulates morphometric neointimal reinforce remodelling restenosis sm22alpha stenotic thymidine transgenic tritiated vsmc	4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop
Tagcloud (Difference) ?		accordance aorta arteries atherosclerosis carotid ciclin d2 expresses functionality hemodynamic hyperplasia immunocitochemistry immunostaining intima labelling ligated ligation modulates morphometric neointimal reinforce remodelling restenosis sm22alpha stenotic thymidine transgenic tritiated vsmc	4th addressed alls bmt bristol characterizing clonospecific confirmation cure dek e2a igh immunoglobulin issues leukaemia lymphoblastic myelogenous offers opportunity presumably purposes quantitate rara rearrangements tcr took truly uk workshop
Tagcloud (Intersection) ?