MMP2 and MMP17

Number of citations of the paper that reports this interaction (PMID 10551873)
7

Data Source:
HPRD (in vitro)

		MMP2	MMP17
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	matrix metallopeptidase 17 (membrane-inserted)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Proteinaceous Extracellular Matrix Integral Component Of Plasma Membrane Anchored Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Proteolysis Positive Regulation Of Catalytic Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Marimastat Captopril SC-74020
Diseases
GWAS			Migraine ( 22683712)
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	3 interactors: LRP1 MMP2 TNF
Entrez ID		4313	4326
HPRD ID		00386	03793
Ensembl ID		ENSG00000087245	ENSG00000198598
Uniprot IDs		P08253	Q8IWC3 Q9ULZ9
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Cellular Response To Amino Acid Stimulus Response To Amino Acid Response To Abiotic Stimulus Negative Regulation Of Branching Involved In Lung Morphogenesis Beta-amyloid Clearance Negative Regulation Of L-glutamate Transport Cellular Response To Acid Chemical Detection Of Abiotic Stimulus Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Regulation Of Neuron Apoptotic Process Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Neuron Death Response To Hypoxia Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Response To External Stimulus Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Transport Necroptotic Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Receptor Biosynthetic Process Transformed Cell Apoptotic Process Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Podosome Assembly Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NFAT Protein Import Into Nucleus Blood Vessel Morphogenesis Activation Of MAPKKK Activity Negative Regulation Of Alkaline Phosphatase Activity Cellular Response To Nicotine Intramembranous Ossification Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Action Potential Cellular Response To Organonitrogen Compound Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Fever Generation Bone Trabecula Formation
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp2 mmp9 mmps nevertheless nude reveals setd1a supporting
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	ablation alteration chip demethylases depletion duplications fundamental h3k4 h3k4me3 hallmark herein hsetd1a link mark mechanistic metalloproteinases metastasis methyltransferase methyltransferases mmp12 mmp13 mmp9 nevertheless nude reveals setd1a supporting
Tagcloud (Intersection) ?		mmp2 mmps