MLH1 and SEC61A1

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	SEC61A1
Gene Name		mutL homolog 1	Sec61 alpha 1 subunit (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Rough Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Protein Binding Ribosome Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent SRP-dependent Cotranslational Protein Targeting To Membrane Posttranslational Protein Targeting To Membrane Endoplasmic Reticulum Organization Cell Growth Response To Interferon-gamma Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Targeting To ER
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Translation SRP-dependent cotranslational protein targeting to membrane Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	6 interactors: ASNA1 BAG6 CALM1 HSPA5 MLH1 SERP1
Entrez ID		4292	29927
HPRD ID		00390	15316
Ensembl ID		ENSG00000076242	ENSG00000058262
Uniprot IDs		P40692 Q59EG3	B3KME8 B3KNF6 P61619
PDB IDs		3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Protein Insertion Into ER Membrane Response To Endoplasmic Reticulum Stress Protein Insertion Into Membrane Membrane Organization Substantia Nigra Development Endoplasmic Reticulum Organization Cellular Localization Synapsis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Homologous Chromosome Segregation Positive Regulation Of Nuclease Activity Endomembrane System Organization Platelet Degranulation Positive Regulation Of Protein Kinase Activity Meiotic Chromosome Segregation Positive Regulation Of Kinase Activity Protein Localization To Organelle Midbrain Development Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Transferase Activity Meiotic Spindle Midzone Assembly Regulation Of Protein Folding In Endoplasmic Reticulum Meiotic Metaphase I Plate Congression Cellular Response To Unfolded Protein Meiosis I ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stress Catabolic Process Cell Activation Response To Unfolded Protein Negative Regulation Of Mitotic Recombination Cerebellum Structural Organization Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Regulation Of Protein Kinase Activity Protein Localization Regulation Of Cellular Protein Metabolic Process Brain Development Regulation Of Kinase Activity Meiotic Nuclear Division Head Development Cellular Macromolecule Catabolic Process System Development Positive Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?