MITF and TFEB

Number of citations of the paper that reports this interaction (PMID 9806910)
25

Data Source:
HPRD (in vivo)

		MITF	TFEB
Gene Name		microphthalmia-associated transcription factor	transcription factor EB
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Protein Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling	Embryonic Placenta Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Autophagy Humoral Immune Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I	4 interactors: MITF SRPK1 TFE3 TFEC
Entrez ID		4286	7942
HPRD ID		01138	02847
Ensembl ID		ENSG00000187098	ENSG00000112561
Uniprot IDs		B4DNC7 O75030 Q8WYR3	B0QYS6 P19484
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated	Regulation Of Osteoclast Differentiation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Myeloid Cell Differentiation RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Sperm Chromatin Condensation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune System Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Viral Genome Replication RNA Biosynthetic Process Spermatid Nucleus Differentiation Melanocyte Differentiation Osteoclast Differentiation Negative Regulation Of Viral Genome Replication Neuroepithelial Cell Differentiation Bone Remodeling Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Developmental Pigmentation Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Viral Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Regulation Of MRNA Processing Canonical Wnt Signaling Pathway Immune Response Regulation Of Immune System Process Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Response To Heat Tissue Remodeling Myeloid Leukocyte Differentiation Pigmentation Nucleus Organization
Tagcloud ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	adaptors alters axonally delays endosomal enlarged enlarges fatal fronto ftld highlighting illumination lamp lobar lumenal lysosomal lysosomes organelle photodamage reporters soma sted tdp tmem106 tmem106b torin traffic transported yields
Tagcloud (Difference) ?		agricultural ammonium b16 coloring cosmetic cosmetics downregulate dyes f10 follicles hair hypopigmenting industry lawsone melanin melanogenesis melanoma microphthalmia modern mushroom permanent persulfate products proved resorcinol semi sodium temporary tyrosinase	adaptors alters axonally delays endosomal enlarged enlarges fatal fronto ftld highlighting illumination lamp lobar lumenal lysosomal lysosomes organelle photodamage reporters soma sted tdp tmem106 tmem106b torin traffic transported yields
Tagcloud (Intersection) ?