MEF2A and MYOG

Number of citations of the paper that reports this interaction (PMID 1329097)
21

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		MEF2A	MYOG
Gene Name		myocyte enhancer factor 2A	myogenin (myogenic factor 4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion	Ossification Cell Cycle Skeletal Muscle Tissue Development Negative Regulation Of Cell Proliferation Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion Positive Regulation Of Myoblast Fusion
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4	35 interactors: BBS4 CALM1 CALM2 CALM3 CARM1 CCDC28A CDH18 CLUAP1 CSRP3 EIF4E2 ELSPBP1 FTL HYPM ID1 ID2 ID3 IKBIP MAPK3 MDFI MEF2A MEF2C MLH1 NF1 PACRGL POLR2C PRMT5 SEPT5 SP1 SRF TAF6L TCF3 TRIM43 TTC25 TXNDC9 YME1L1
Entrez ID		4205	4656
HPRD ID		02807	01167
Ensembl ID		ENSG00000068305	ENSG00000122180
Uniprot IDs		Q02078	P15173
PDB IDs		1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process	Cell Activation Positive Regulation Of Phosphatase Activity Heart Development Organ Morphogenesis Positive Regulation Of Dephosphorylation Anatomical Structure Development Organ Development Cardiac Myofibril Assembly Determination Of Heart Left/right Asymmetry Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Anatomical Structure Morphogenesis Regulation Of Heart Contraction Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Cellular Metabolic Process Developmental Process Cardiovascular System Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Development Embryonic Organ Morphogenesis Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Binding Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Phosphatase Activity Organelle Organization System Development Determination Of Left/right Symmetry Multicellular Organismal Development Neurotrophin TRK Receptor Signaling Pathway Determination Of Bilateral Symmetry Neurotrophin Signaling Pathway Response To Calcium Ion Positive Regulation Of Lyase Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Tissue Development Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of Dephosphorylation Detection Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Communication By Electrical Coupling Regulation Of Adenylate Cyclase Activity Muscle System Process Cell Development
Tagcloud ?		blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myod myogenesis myogenic myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Difference) ?		blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Intersection) ?		myod myogenesis myogenic