MCAM and ADRB2

Number of citations of the paper that reports this interaction (PMID 24561123)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		MCAM	ADRB2
Gene Name		melanoma cell adhesion molecule	adrenoceptor beta 2, surface
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function		Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding
	Biological Process	Angiogenesis Glomerular Filtration Cell Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Vascular Wound Healing	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ADRB2 ATF7IP FYN PTK2B	88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		4162	154
HPRD ID		01120	00187
Ensembl ID		ENSG00000076706	ENSG00000169252
Uniprot IDs		P43121	P07550
PDB IDs			1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO
Enriched GO Terms of Interacting Partners?		Bone Resorption Peptidyl-tyrosine Autophosphorylation Bone Remodeling Regulation Of Bone Mineralization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Intracellular Signal Transduction Response To Ethanol Positive Regulation Of Protein Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Shape Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Tissue Homeostasis Response To Abiotic Stimulus Regulation Of Ossification Negative Regulation Of Neuron Death Protein Autophosphorylation Regulation Of Protein Ubiquitination Response To Mechanical Stimulus Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Neuron Projection Development Regulation Of Neuron Apoptotic Process Multicellular Organismal Homeostasis Positive Regulation Of Signal Transduction Activation Of Janus Kinase Activity Activation Of Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Neuron Death Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heat Generation Diet Induced Thermogenesis Positive Regulation Of Neuron Differentiation Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Cellular Protein Complex Assembly Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain	Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		adhesion baseline cec cecs cellsearch circulating combining correlations counts ctc ctcs cytometry deserves detection enriched enrichment epcam explored improve melanoma molecule nac neoadjuvant neozotac next pbc relevance separately starting	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Difference) ?		adhesion baseline cec cecs cellsearch circulating combining correlations counts ctc ctcs cytometry deserves detection enriched enrichment epcam explored improve melanoma molecule nac neoadjuvant neozotac next pbc relevance separately starting	acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra
Tagcloud (Intersection) ?