MAD2L1 and REV3L

Number of citations of the paper that reports this interaction (PMID 10660610)
51

Data Source:
BioGRID (pull down)

		MAD2L1	REV3L
Gene Name		MAD2 mitotic arrest deficient-like 1 (yeast)	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nuclear Pore Cytosol Perinuclear Region Of Cytoplasm Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Zeta DNA Polymerase Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of APC-Cdc20 Complex Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis
Pathways		Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase	Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS		F-cell distribution ( 21326311) HIV-1 viral setpoint ( 22174851)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		20 interactors: ADAM17 ANAPC2 APP CDC16 CDC20 CDC27 CSF2RB ESR2 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TSC22D4 UBD	5 interactors: CHEK2 HDAC4 MAD2L1 MAD2L2 REV1
Entrez ID		4085	5980
HPRD ID		03274	04145
Ensembl ID			ENSG00000009413
Uniprot IDs		Q13257	O60673
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Mitotic Cell Cycle Checkpoint Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Regulation Of Cellular Component Organization Mitotic Nuclear Division Negative Regulation Of Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Processing Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Protein Ubiquitination Regulation Of Proteolysis Cell Division Negative Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process	Negative Regulation Of APC-Cdc20 Complex Activity Mitotic Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Nuclear Division Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Signal Transduction In Response To DNA Damage DNA Repair Negative Regulation Of Protein Ubiquitination Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Cell Cycle Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Tagcloud ?		aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle	adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h
Tagcloud (Difference) ?		aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle	adriamycin cgi cgis cox7a2l cpg damaging deal distinctly enrichment hct116 hnrpul1 island jag2 mildly pcna peroxidase phenomena repressed scenarios scfd2 stabilize stabilized stresses syvn1 tor1aip1 unchanged varies verified xpmc2h
Tagcloud (Intersection) ?