LTF and CD14

Number of citations of the paper that reports this interaction (PMID 11083760)
15

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LTF	CD14
Gene Name		lactotransferrin	CD14 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Specific Granule Extracellular Vesicular Exosome Phagocytic Vesicle Lumen	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Endosome Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Serine-type Endopeptidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding
	Biological Process	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Transcription, DNA-templated Proteolysis Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Iron Assimilation By Chelation And Transport Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Osteoblast Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Interaction With Host Response To Host Immune Response Bone Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Phagosome Maturation Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Response To Magnesium Ion Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid
Pathways		Amyloids Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Response of Mtb to phagocytosis Mtb iron assimilation by chelation	TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Transfer of LPS from LBP carrier to CD14 Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs		3h-Indole-5,6-Diol Alpha-D-Mannose Nitrilotriacetic Acid Alpha-D-Fucose Nimesulide 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE parecoxib
Diseases
GWAS		AIDS progression ( 21502085)
Protein-Protein Interactions		9 interactors: CALM1 CD14 CEL CP ITLN1 LCN1 LRP1 LYZ MUC7	14 interactors: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		4057	929
HPRD ID		01028	01151
Ensembl ID		ENSG00000012223	ENSG00000170458
Uniprot IDs		E7ER44 P02788	P08571
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS	4GLP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Retina Homeostasis Alcohol Metabolic Process Response To External Stimulus Phototransduction, Visible Light Beta-amyloid Clearance Protein Esterification Intestinal Lipid Catabolic Process Regulation Of Phospholipase Activity Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Multicellular Organismal Lipid Catabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Detection Of Abiotic Stimulus Response To Other Organism Tissue Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Biotic Stimulus Pancreatic Juice Secretion Response To Nematode Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intestinal Cholesterol Absorption Multicellular Organismal Homeostasis Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Steroid Metabolic Process Phagocytosis Detection Of Calcium Ion Regulation Of Phospholipase A2 Activity Cholesterol Catabolic Process Lipid Digestion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Lipid Transport Cellular Response To Lipoteichoic Acid Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Metal Ion Lipid Localization Negative Regulation Of Smooth Muscle Cell Migration Response To Magnesium Ion Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus	Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Other Organism Response To Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Response To Bacterium Defense Response Regulation Of Inflammatory Response Positive Regulation Of Immune System Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune Response Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Response To Stress Defense Response To Bacterium Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Inflammatory Response Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Response To External Stimulus I-kappaB Phosphorylation Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Difference) ?		ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Intersection) ?