LSP1 and ACTG1

Number of citations of the paper that reports this interaction (PMID 10925289)
3

Data Source:
HPRD (in vitro)

		LSP1	ACTG1
Gene Name		lymphocyte-specific protein 1	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Signal Transducer Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Chemotaxis Cellular Defense Response Signal Transduction	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Breast cancer ( 17529967 23535729 20453838) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		3 interactors: ACTG1 BMPR2 MAPKAPK2	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		4046	71
HPRD ID		01083	00017
Ensembl ID		ENSG00000130592	ENSG00000184009
Uniprot IDs		P33241	P63261
PDB IDs		3BH8
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Signal Transduction By Phosphorylation Response To External Stimulus Macropinocytosis Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Immune Response-regulating Signaling Pathway 3'-UTR-mediated MRNA Stabilization Lymphangiogenesis Lymph Vessel Morphogenesis Sensory Organ Development Pinocytosis Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Immune Response Venous Blood Vessel Development Endocytosis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Response To Stress MRNA Stabilization Innate Immune Response Regulation Of Cellular Response To Heat Activin Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Immune Response Leukotriene Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process G2 DNA Damage Checkpoint Chondrocyte Development Positive Regulation Of BMP Signaling Pathway Platelet Aggregation Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development System Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Anatomical Structure Formation Involved In Morphogenesis	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		afi ai basic cellulose chemotactic cytoskeletal deae designated gilchrist heat huang hyd labadia lysate mapkap microsequencing p60 polyacrylamide positions react sds serine sha stresses surrounding transferase xaa y zu	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		afi ai basic cellulose chemotactic cytoskeletal deae designated gilchrist heat huang hyd labadia lysate mapkap microsequencing p60 polyacrylamide positions react sds serine sha stresses surrounding transferase xaa y zu	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?