LPA and MMP12

Number of citations of the paper that reports this interaction (PMID 10187779)
3

Data Source:
HPRD (in vitro)

		LPA	MMP12
Gene Name		lipoprotein, Lp(a)	matrix metallopeptidase 12 (macrophage elastase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Lipoprotein Particle	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Apolipoprotein Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Blood Circulation Negative Regulation Of Endopeptidase Activity Lipoprotein Metabolic Process Small Molecule Metabolic Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Pathways			Collagen degradation Degradation of the extracellular matrix
Drugs		Aminocaproic Acid	Acetohydroxamic Acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4\'-Ethoxy-1,1\'-Biphenyl-4-Yl)-4-Oxobutanoic Acid (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
Diseases
GWAS		Aortic-valve calcification ( 23388002) Cholesterol, total ( 20686565) Coronary heart disease ( 19198611 21378990) HDL cholesterol ( 20686565) LDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Lp (a) levels ( 21900290 19124843) Monocyte early outgrowth colony forming units ( 21493818) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statin therapy (LDL-C) ( 22331829)	Alzheimer's disease ( 22832961)
Protein-Protein Interactions		9 interactors: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12	5 interactors: APP F12 LPA PLAUR TFPI
Entrez ID		4018	4321
HPRD ID		01063	03027
Ensembl ID		ENSG00000198670
Uniprot IDs			P39900
PDB IDs			1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Wound Healing Response To Wounding Extracellular Matrix Disassembly Blood Coagulation Hemostasis Cell-matrix Adhesion Response To Stress Regulation Of Body Fluid Levels Secretion Cell-substrate Adhesion Vesicle-mediated Transport Collagen Catabolic Process Platelet Degranulation Acute Inflammatory Response Collagen Metabolic Process Transport Multicellular Organismal Macromolecule Metabolic Process Inflammatory Response Multicellular Organismal Metabolic Process Secretion By Cell Neutrophil Mediated Killing Of Fungus Protein Metabolic Process Defense Response Triglyceride Transport Response To Stimulus Regulation Of Growth Regulation Of Cell Proliferation Calcium-independent Cell-matrix Adhesion Endocytosis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Pancreas Morphogenesis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Platelet Activation Elastic Fiber Assembly Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Cell Migration Leukocyte Migration Plasminogen Activation Acute Inflammatory Response To Antigenic Stimulus Exocrine Pancreas Development Negative Regulation Of Locomotion Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Fibrinolysis	Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Urokinase Plasminogen Activator Signaling Pathway Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Factor XII Activation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Protein Activation Cascade Lipoprotein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Metabolic Process Positive Regulation Of Fibrinolysis Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Plasminogen Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Lipid Metabolic Process Neuron Remodeling Response To Stress Protein Autoprocessing Plasma Kallikrein-kinin Cascade Attachment Of GPI Anchor To Protein Regulation Of Fibrinolysis Regulation Of Metabolic Process Blood Coagulation, Intrinsic Pathway Response To Misfolded Protein Cellular Copper Ion Homeostasis Positive Regulation Of Protein Processing
Tagcloud ?		adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl
Tagcloud (Difference) ?		adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting	2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl
Tagcloud (Intersection) ?