RHOH and LRIF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RHOH	LRIF1
Gene Name		ras homolog family member H	ligand dependent nuclear receptor interacting factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane	Nucleus Microtubule Organizing Center Actin Cytoskeleton Nuclear Matrix
	Molecular Function	GTPase Inhibitor Activity Protein Binding GTP Binding Rho GTPase Binding Kinase Inhibitor Activity	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Small GTPase Mediated Signal Transduction T Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Activation Regulation Of Small GTPase Mediated Signal Transduction	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Graves' disease ( 21841780)
Protein-Protein Interactions		8 interactors: ARHGDIA ARHGDIB ARHGDIG GDI1 KCNH2 LRIF1 TGFBR1 UTP14A	129 interactors: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRADD CRCT1 DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 HAP1 HIST3H3 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NHP2L1 NOC2L NR3C1 NRBP1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR2C POLR3F PPARG PQBP1 PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TDGF1 TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSPAN6 UBE2V2 VIM WDR62 WWC1 ZNF24
Entrez ID		399	55791
HPRD ID		03616	17975
Ensembl ID			ENSG00000121931
Uniprot IDs		Q15669 Q6ICP4	Q5T3J3
PDB IDs
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Rho Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Adhesion Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Negative Regulation Of Axonogenesis Positive Regulation Of Hydrolase Activity Negative Regulation Of Potassium Ion Export Regulation Of Cell Morphogenesis Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Heart Rate By Hormone Negative Regulation Of Neuron Projection Development Regulation Of Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Regulation Of Cellular Component Movement Negative Regulation Of Cell Differentiation Regulation Of Signaling Negative Regulation Of Neuron Differentiation Negative Regulation Of Protein Targeting To Membrane Signal Transduction Regulation Of Cell Development Positive Regulation Of Metabolic Process Parathyroid Gland Development Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Signaling Regulation Of Intracellular Protein Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of Cell Projection Organization Potassium Ion Export Endothelial Cell Activation Negative Regulation Of Neurogenesis Pathway-restricted SMAD Protein Phosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Potassium Ion Transmembrane Transport	Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Protein Metabolic Process System Development Regulation Of Gene Expression Developmental Process Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Multicellular Organismal Development Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Nervous System Development Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Macromolecule Biosynthetic Process Response To Organic Substance Cellular Metabolic Process Response To Stress Positive Regulation Of Apoptotic Process Response To Steroid Hormone Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Regulation Of Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Organic Substance Regulation Of Cell Cycle
Tagcloud ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis	aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Difference) ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis	aging apply characterizing composition dysfunctional enrich immunopurified involves isolation isotope labelling polypeptides pot1 qtip shelterin shelterins silac smchd1 states syndromes telomere telomeres telomeric tho tin2 tpp1 trf1 tumourigenesis validate
Tagcloud (Intersection) ?