LIMK1 and SSH3

Number of citations of the paper that reports this interaction (PMID 15660133)
61

Data Source:
HPRD (in vitro)

		LIMK1	SSH3
Gene Name		LIM domain kinase 1	slingshot protein phosphatase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection	Nucleus Cytoplasm Cytoskeleton
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity	DNA Binding Actin Binding Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly	Protein Dephosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Axonogenesis
Pathways		EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ	4 interactors: ACTB APP CFL1 LIMK1
Entrez ID		3984	54961
HPRD ID		03210	09488
Ensembl ID		ENSG00000106683	ENSG00000172830
Uniprot IDs		P53667	C9JUG3 Q8TE77
PDB IDs		3S95
Enriched GO Terms of Interacting Partners?		Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process	Axon Guidance Axonogenesis Ephrin Receptor Signaling Pathway Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Platelet Activation Neuron Development Cell Morphogenesis Phagocytosis Neuron Differentiation Cell Projection Organization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Immune Response Defense Response Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Generation Of Neurons Blood Coagulation Hemostasis Neurogenesis Immune Response-regulating Signaling Pathway Rho Protein Signal Transduction Cell Development Response To External Stimulus Regulation Of Neuron Differentiation Platelet Degranulation Regulation Of Body Fluid Levels Wound Healing Immune System Process Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Cell Activation Response To Wounding Regulation Of Neurogenesis Anatomical Structure Morphogenesis
Tagcloud ?		alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Difference) ?		alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Intersection) ?